False-Positive DaTscan Features With Methylphenidate and Phentermine Therapy.
False-Positive DaTscan Features With Methylphenidate and Phentermine Therapy.
复制标题
哌醋甲酯和芬特明治疗出现假阳性 DaTscan 特征。
DOI：
10.1016/j.mayocp.2018.09.012
复制
发表时间：
2018
影响因子：
8.9
通讯作者：
B. Nguyen
中科院分区：
文献类型：
--
作者：
K. Huynh;B. Nguyen
案例1。一名64岁男性震颤患者的初始多巴胺转运体单光子发射计算机断层扫描（SPECT）成像（DaTscan）显示纹状体示踪剂异常斑片状分布（图1，上排）。未指示患者在检查前停用哌甲酯。停药25天后再次进行DaTscan，纹状体特征正常（图1，下一行）。例2。一名36岁帕金森女性患者的初始DaTscan显示纹状体示踪剂分布弥漫性不均匀，靶本活动比低（图2，上排）。她没有按照指示在成像前停用芬特明。停药19天后，重复DaTscan显示纹状体特征正常，靶本比高（图2，下行）。
Case 1. A 64-year-old man with tremors had the initial Dopamine transporter single-photon emission computerized tomography (SPECT) imaging (DaTscan) showing abnormally patchy striatal tracer distribution (Figure 1, top row). The patient was not instructed to stop methylphenidate before the examination. A repeat DaTscan, 25 days later with drug discontinuation, showed normal striatal features (Figure 1, bottom row).Case 2. A 36-year-old woman with parkinsonism had the initial DaTscan showing diffusely heterogeneous striatal tracer distribution with low target-to-background activity ratio (Figure 2, top row). She did not follow the instruction to stop phentermine before the imaging. A repeat DaTscan, 19 days later with drug discontinuation, showed normal features with high striatum target-to-background ratio (Figure 2, bottom row).