ANTAGONISM OF EFFECTS OF FUROSEMIDE BY INDOMETHACIN IN NORMAL AND HYPERTENSIVE MAN
ANTAGONISM OF EFFECTS OF FUROSEMIDE BY INDOMETHACIN IN NORMAL AND HYPERTENSIVE MAN
复制标题
DOI：
10.1016/s0090-6980(75)80012-8
复制
发表时间：
1975-01-01
影响因子：
2.9
通讯作者：
LEE, JB
中科院分区：
文献类型：
--
作者：
PATAK, RV;MOOKERJEE, BK;LEE, JB
对 4 名正常受试者和 6 名原发性高血压患者单独或联合给予速尿和前列腺素合成酶抑制剂吲哚美辛，以确定速尿是否可以通过抑制前列腺素合成来改变其降压、利钠和其他作用。在所有受试者中，单独使用吲哚美辛治疗会导致血压显着升高和血浆肾素下降，而钠排泄没有任何变化。单独使用速尿会导致血压显着下降，血浆肾素和尿醛固酮升高，尿钠丢失显着增加。添加吲哚美辛可以消除或减弱这些影响。结果与呋塞米的抗高血压和利尿钠作用可能至少部分由前列腺素合成介导的假设相一致。在高血压患者和需要利尿治疗的受试者中使用该药物时，应考虑吲哚美辛的影响。
Furosemide and the prostaglandin synthetase inhibitor, indomethacin, were administered singly and in combination to 4 normal subjects and 6 patients with essential hypertension to determine whether the antihypertensive, natriuretic and other effects of furosemide could be altered by inhibition of prostaglandin synthesis. In all subjects indomethacin treatment alone resulted in a significant elevation of blood pressure and a fall in plasma renin without any change in Na excretion. Furosemide alone resulted in a significant blood pressure fall with a rise in plasma renin and urinary aldosterone with a marked increase in urinary Na loss. These effects were either obviated or blunted by addition of indomethacin. The results are compatible with the hypothesis that the antihypertensive and natriuretic effects of furosemide might be mediated at least in part by prostaglandin synthesis. The effects of indomethacin should be considered when using this drug in hypertensive patients and in subjects requiring diuretic therapy.