Asymmetric synthesis of tetrasubstituted cyclic amines via aza-Henry reaction using cinchona alkaloid sulfonamide/zinc(II) catalysts
Asymmetric synthesis of tetrasubstituted cyclic amines via aza-Henry reaction using cinchona alkaloid sulfonamide/zinc(II) catalysts
复制标题
金鸡纳生物碱磺酰胺/锌(II)催化剂通过氮杂亨利反应不对称合成四取代环胺
DOI：
10.1039/d1cc06492d
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发表时间：
2022
影响因子：
4.9
通讯作者：
Nakamura Shuichi
中科院分区：
文献类型：
--
作者：
Yasukawa Naoki;Yamanoue Ami;Takehara Tsunayoshi;Suzuki Takeyuki;Nakamura Shuichi
首次报道了由环状氨基酸衍生的非活化环状亚氨酯的对映选择性氮杂-亨利反应。良好的产率和对映体选择性的反应，观察到使用我们原来的金鸡纳生物碱磺酰胺/锌（II）催化剂。通过实验和密度泛函理论计算，提出了过渡态的概念来解释立体选择性。
The first enantioselective aza-Henry reaction of non-activated cyclic iminoesters, derived from cyclic amino acids, has been developed. Good yields and enantioselectivities were observed for the reaction using our original cinchona alkaloid sulfonamide/zinc(II) catalyst. The transition state was proposed to explain the stereoselectivity based on experiments and DFT calculations.