We could predict good responders to vagus nerve stimulation: A surrogate marker by slow cortical potential shift
We could predict good responders to vagus nerve stimulation: A surrogate marker by slow cortical potential shift
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我们可以预测对迷走神经刺激有良好反应的人：通过缓慢的皮质电位变化作为替代标记
DOI：
10.1016/j.clinph.2017.05.019
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发表时间：
2017
影响因子：
4.7
通讯作者：
Ikeda Akio
中科院分区：
文献类型：
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作者：
Bayasgalan Borgil;Matsuhashi Masao;Fumuro Tomoyuki;Nohira Haruhiko;Nakano Naoki;Iida Koji;Katagiri Masaya;Shimotake Akihiro;Matsumoto Riki;Kikuchi Takayuki;Kunieda Takeharu;Kato Amami;Takahashi Ryosuke;Ikeda Akio
我们研究迷走神经刺激（VNS）是否会导致癫痫发作减少>50%（应答者）的患者的慢皮层电位（SCP）发生正移，但在nonrespons.MethodsWe分析了24例接受VNS癫痫发作治疗的患者的常规临床脑电图（EEG）。根据脑电图硬件时间常数（TC）分为TC 10-s组（10例）和TC 2-s组（14例）。我们比较了5个电极（Cz和相邻电极）在VNS的2种状态之间的SCP：刺激期间和刺激之间。独立判断癫痫发作减少。结果TC 10-s组SCP与癫痫发作减少有显著相关性（P < 0.05）（即SCP阳性与否与癫痫发作减少>50%或无相关性），而TC 10-s组SCP与癫痫发作减少无显著相关性（P> 0.05）。4中的两个良好结果和5中的两个阴性结果）。TC 2 s组SCP与癫痫发作减少无显著相关性（p= 0.2 0 9）。结论TC 10 s记录的SCP正移可作为VNS反应的替代指标，SCP可作为VNS反应良好的生物标志物。
ObjectiveWe investigated whether vagus nerve stimulation (VNS) induces a positive shift of slow cortical potentials (SCPs) in patients with >50% seizure reduction (responders) but not in non-responders.MethodsWe analyzed routine clinical electroencephalograms (EEGs) from 24 patients who were undergoing seizure treatment by VNS. The patients were divided into 2 groups by hardware time constant (TC) of EEG: the TC 10-s group (10 patients) and TC 2-s group (14 patients). We compared SCPs at 5 electrodes (Cz and adjacent ones) between the 2 states of VNS: during stimulation and between stimulations. Seizure reduction was independently judged. Correlation between SCP (positivity or not) and seizure reduction (>50% or not) was estimated.ResultsIn the TC 10-s group, the correlation between SCP and seizure reduction was significant (p< 0.05) (i.e., both good results in 4 and both negative results in 5). In TC 2-s group, the correlation between SCP and seizure reduction was not significant (p= 0.209).ConclusionsA positive shift of SCP recorded by using a TC of 10 s could be a surrogate marker for VNS response.SignificanceSCP could be a biomarker of good responders to VNS.