Are there any differences in colorectal cancer between young and elderly patients?
Are there any differences in colorectal cancer between young and elderly patients?
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DOI：
10.1007/s10151-004-0139-4
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发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Hatzitheoharis, G
中科院分区：
文献类型：
--
作者：
Frizis, H;Papadopoulos, A;Hatzitheoharis, G
背景：关于结直肠癌（CRC）在年轻人群中是否比在老年人群中更具侵袭性，因此预后较差，存在争议。本研究的目的是回顾10年间（1994-2003）诊断为结直肠癌的年轻和老年患者的治疗结果。方法：我们研究了在第一外科接受手术的两个不同年龄组：年轻人（40岁以下）和老年人（80岁以上）。其中11例患者年龄在37 - 40岁之间（平均年龄39岁）。老年人45例，年龄81 ~ 91岁，平均年龄86岁。我们比较了临床体征、病理分级、Dukes分期和有无转移、平均住院时间和术后死亡率。结果：诊断为急腹症的住院患者中，年轻人占9%，老年人占7%。Dukes分期为C期，青年组为54.5%，老年组为44.4%。未分化腺癌在年轻人中占36.3%，在老年人中占8.8%。手术中，18%的年轻人和24.4%的老年人发现远端转移。青年和老年患者的平均住院时间分别为13天和15.2天。青年和老年患者术后死亡率分别为0%和4%。结论：除了年轻患者的未分化腺癌发生率较高外，两个年龄组之间的比较因素没有特别的差异。死亡率并不表明年轻人的预后较差。
BACKGROUND: There is a controversy as to whether colorectal cancer (CRC) in the young population is more aggressive than in the elderly population, and hence has a less favourable prognosis. The aim of this study is to review the results of treatment of young and elderly patients diagnosed with CRC during a 10-year period (1994-2003).METHODS: We studied two distinct age groups: young (aged under 40) and elderly (aged over 80), who underwent surgery in the 1st Surgical Department. The young consisted of 11 patients with ages ranging from 37 to 40 (average age 39). The elderly consisted of 45 patients with ages ranging from 81 to 91 (average age 86). We compared clinical signs, pathological grade, Dukes' stage and presence of metastasis, average hospitalisation time, and postoperative mortality.RESULTS: The results of patients admitted to hospital with a diagnosis of acute abdomen were 9% in the young and 7% of the elderly. Those in stage C in Dukes' classification were 54.5% in the young group, and 44.4% in the elderly group. Those with undifferentiated adenocarcinoma were 36.3% in the young, and 8.8% in the elderly. During surgery, distal metastases were found in 18% of the young and 24.4% of the elderly. The average hospitalisation time of young and elderly patients was 13 and 15.2 days, respectively. The postoperative mortality rates of the young and elderly patients were 0% and 4%, respectively.CONCLUSIONS: Except for a higher rate of undifferentiated adenocarcinoma in young patients, there were no particular differences in the compared factors between the two age groups. The mortality rates do not indicate a less favourable prognosis for the young.