Self-assembled soft nanofibrils of amphipathic polypeptides and their morphological transformation
Self-assembled soft nanofibrils of amphipathic polypeptides and their morphological transformation
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DOI：
10.1021/cm048196f
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发表时间：
2005-05-17
影响因子：
8.6
通讯作者：
Akashi, M
中科院分区：
文献类型：
--
作者：
Kaneko, T;Higashi, M;Akashi, M
通过对苯丙氨酸乙酯的修饰，制备了具有两亲性结构的聚γ-谷氨酸（poly（γ-glutamic acid）），并通过弱自组装形成纳米纤维。通过控制水的组成，进一步改变环境，纳米纤丝转变为纳米球和纳米片。我们认为这种新型的动态纳米纤维对于刺激响应的生物纳米颗粒是非常重要的。
We have prepared poly(γ-glutamic acid) amphipathically structured by a modification ofl-phenylalanine ethyl which formed weakly self-assembled nanofibrils. The nanofibrils transformed into nanospheres and nanoplatelets upon further environmental changes exerted by controlling the water composition. We consider the novel dynamic nanofibrils are very important for stimuli-responsive bionanoparticles.