The Urticaria Severity Score: a sensitive questionnaire/index for monitoring response to therapy in patients with chronic urticaria
The Urticaria Severity Score: a sensitive questionnaire/index for monitoring response to therapy in patients with chronic urticaria
复制标题
DOI：
10.1016/s1081-1206(10)60120-2
复制
发表时间：
2009-06-01
影响因子：
5.9
通讯作者：
Rosenstreich, David
中科院分区：
文献类型：
--
作者：
Jariwala, Sunit P.;Moday, Heather;Rosenstreich, David
背景：尽管存在大量针对皮肤科的生活质量调查问卷，但仍需要一种有效的工具来评估和监测慢性荨麻疹患者。目的：开发和验证一种新的针对慢性荨麻疹的调查问卷--荨麻疹严重程度评分(USS)。USS在28名有症状的慢性荨麻疹患者身上进行了初步测试，并在80名患者中进行了改良版本的测试。在后一组中，USS与先前验证的皮肤病生活质量指数(DLQI)进行了比较。患者在基线和随访时(中位数为2周)完成了这两份问卷。采用Spearman等级相关检验比较USS和DLQI。结果：在基线(r=0.64)和随访(r=0.69)时，USS与DLQI呈正相关。USS的重测信度相关良好(r=0.96)(P=.001)。在检测症状改善方面，USS比DLQI更敏感。USS从基线到随访的平均(SD)“原始评分”变化为9.95(12.80)，而DLQI从基线到随访的平均变化(SD)为2.25(4.87)。结论：USS是一个有效和可靠的工具来监测麻疹的严重程度。USS比DLQI更敏感地量化了荨麻疹的严重程度，并且可能更适用于评估针对荨麻疹的治疗效果。过敏性哮喘免疫。2009；102：475-482。
Background: Despite the existence of numerous dermatology-specific quality-of-life questionnaires, there exists a need for a well-validated instrument to evaluate and monitor patients with chronic urticaria.Objective: To develop and validate a novel chronic urticaria-specific questionnaire, the Urticaria Severity Score (USS).Methods: The USS was developed with 12 questions and 7 response options per question included in the final questionnaire. The USS was pilot tested on 28 patients with symptomatic chronic urticaria, and a modified version was tested in 80 patients. In this latter group, the USS was compared with the previously validated Dermatology Life Quality Index (DLQI). Patients completed both questionnaires at baseline and at follow-up (median, 2 weeks). Spearman rank correlation tests were used to compare the USS with the DLQI. At a subsequent visit, 9 additional patients completed the USS to evaluate test-retest reliability.Results: There was a positive correlation between the USS and DLQI at baseline (r = 0.64) and follow-up (r = 0.69). The test-retest reliability correlation for the USS was adequate (r = 0.96) (P =.001). The USS was more sensitive in detecting symptom improvement than the DLQI. The mean (SD) "raw score" change from baseline to follow-up for the USS was 9.95 (12.80), whereas the mean (SD) change from baseline to follow-up for the DLQI was 2.25 (4.87).Conclusions: The USS is a valid and reliable instrument for monitoring urticaria severity. The USS is more sensitive than the DLQI for quantifying urticaria severity and may be more applicable in the evaluation of urticaria-specific treatment efficacy. Ann Allergy Asthma Immunol. 2009; 102:475-482.