Interactions of Candida albicans with other Candida spp. and bacteria in the biofilms
Interactions of Candida albicans with other Candida spp. and bacteria in the biofilms
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DOI：
10.1111/j.1365-2672.2004.02213.x
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发表时间：
2004-01-01
影响因子：
4
通讯作者：
Khardori, N
中科院分区：
文献类型：
--
作者：
El-Azizi, MA;Starks, SE;Khardori, N
目的：研究白念珠菌与其他12种念珠菌和细菌在生物膜中的相互作用。方法和结果：在聚苯乙烯管模型中，加入念珠菌后，测量生长生物膜内的细胞数。白色念珠菌与其他微生物的预形成生物膜，反之亦然。同时在C.白色念珠菌和其他微生物。C.当真菌加入到念珠菌预形成的生物膜中时，生长生物膜中的白色念珠菌显著减少（P < 0.05）。和细菌，除了C.近平滑球拟酵母（Torulopsis glabrata）和产糖萼的铜绿假单胞菌（Pseudomonas aeruginosa）。当C.将近平滑葡萄球菌、表皮葡萄球菌（非葡萄糖萼产生菌）或粘质沙雷氏菌加入到C.结论：白色念珠菌生物膜中的细胞数量增多，细胞数量增多。白色念珠菌能够容纳其他微生物，更可能与环境中和医疗器械上的其他细菌和真菌异质。研究的意义和影响：认识到生物膜相关微生物的异质性会影响治疗决策，特别是在对初始适当治疗无反应的患者中。
Aims: To study the interactions between Candida albicans and 12 other species of Candida and bacteria in biofilms.Methods and Results: The number of cells within growing biofilms in a polystyrene tube model was measured after adding C. albicans to preformed biofilms of other micro-organisms and vice versa. It was also measured after simultaneous biofilm formation of C. albicans and other micro-organisms. The number of cells of C. albicans within the growing biofilms decreased significantly (P < 0.05) when the fungus was added to preformed biofilms of Candida spp. and bacteria except, with C. parapsilosis, Torulopsis glabrata and the glycocalyx producer Pseudomonas aeruginosa. When C. parapsilosis, Staphylococcus epidermidis (nonglycocalyx producer) or Serratia marcescens was added to preformed biofilms of C. albicans, the number of cells of these micro-organisms increased in the growing biofilms.Conclusions: Biofilms of C. albicans are capable of holding other micro-organisms and more likely to be heterogeneous with other bacteria and fungi in the environment and on medical devices.Significance and Impact of the Study: Recognition of the heterogeneity of biofilm-associated organisms can influence treatment decisions, particularly in patients who do not respond to initial appropriate therapy.