Spatial learning and hippocampal volume in male deer mice: Relations to age, testosterone and adrenal gland weight
Spatial learning and hippocampal volume in male deer mice: Relations to age, testosterone and adrenal gland weight
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DOI：
10.1016/s0306-4522(98)00131-6
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发表时间：
1998-10-01
期刊：
影响因子：
3.3
通讯作者：
Ossenkopp, KP
中科院分区：
文献类型：
--
作者：
Perrot-Sinal, TS;Kavaliers, M;Ossenkopp, KP
对老年（57月龄）、中年（38月龄）、成年（18月龄）和青年（3 ~ 3.5月龄）雄性马尼拉鼠（Peromyscusmaniculatus）的空间学习能力和各项生理指标进行了测定。中年和成年小鼠相对于年轻的繁殖活跃（育种）小鼠在水迷宫任务的收购过程中的性能没有显着降低。在训练的第4阶段，相对于年轻的育种小鼠，老年小鼠的表现恶化。然而，相对于年轻的育种小鼠，这三个老年组的空间任务的保留减少。校正海马体积（校正脑重量）减少，只有在老年小鼠相对于年轻的育种小鼠，虽然海马的绝对体积较低，在所有组相对于年轻的育种小鼠。与年轻的育种小鼠相比，老年小鼠的血浆睾酮水平较低，大脑也较轻。相对于一组年轻的生殖静止雄性（非繁殖）小鼠，老年、中年和成年小鼠的空间保持能力并不缺乏。年轻的育种小鼠表现出更好的空间性能，并有显着较高的血浆睾酮水平，校正海马体积和脑重量相对于年轻的非育种mice.These结果表明，保留的空间任务是更敏感的年龄比收购的任务的雄性鹿小鼠。海马体积，虽然一个总的形态特征，似乎是敏感的雄性鹿鼠老化的影响。血浆睾酮水平似乎不是一个关键因素的基础上与年龄相关的赤字保留的空间任务。(C)1998年IBRO。出版社：Elsevier Science Ltd
Spatial learning and various physiological parameters were examined in old (57 month), middle aged (38 month), adult (18 month) and young (3-3.5 month) male deer mice (Peromyscus maniculatus). Performance during acquisition of a water maze task was not significantly reduced for middle aged and adult mice relative to young reproductively active (breeding) mice. Performance was deteriorated in old mice relative to young breeding mice on block 4 of training. Retention of this spatial task, however, was reduced in all three older groups relative to young breeding mice. Corrected hippocampal volume (corrected for brain weight) was reduced only in old mice relative to young breeding mice although absolute volumes of hippocampus were lower in all groups relative to young breeding mice. Old mice also were shown to have lower levels of plasma testosterone and lighter brains relative to young breeding mice. Spatial retention was not deficient in old, middle aged and adult mice relative to a group of young reproductively quiescent male (non-breeding) mice. Young breeding mice displayed better spatial performance and had significantly higher plasma testosterone levels, corrected hippocampal volume and brain weight relative to young non-breeding mice.These results indicate that retention of a spatial task is more sensitive to the age of male deer mice than acquisition of the task. Hippocampal volume, although a gross morphological feature, appears to be sensitive to the effects of ageing in male deer mice. Plasma testosterone levels do not appear to be a crucial factor underlying age-related deficits in retention of a spatial task. (C) 1998 IBRO. Published by Elsevier Science Ltd.