Bone lead mobilization in lactating mice and lead transfer to suckling offspring.
Bone lead mobilization in lactating mice and lead transfer to suckling offspring.
复制标题
哺乳期小鼠的骨铅动员以及铅向哺乳后代的转移。
DOI：
10.1016/0041-008x(80)90083-6
复制
发表时间：
1980
影响因子：
3.8
通讯作者：
Doherty,RA
中科院分区：
文献类型：
--
作者：
Keller,CA;Doherty,RA
给成年雌性小鼠在交配前105d或交配前105d，以及妊娠和哺乳期(共暴露160d)饮用含铅200μg/ml的饮用水。在哺乳期，与非哺乳期雌性小鼠相比，交配前暴露的成年小鼠的铅排除率更高。哺乳期间额外排出的铅的幅度与哺乳期间股骨灰重下降的幅度相似。这些数据支持这一假说，即哺乳期铅的动员是骨矿物质动员的结果。由于铅在乳汁中的转移，在交配前暴露于铅的母亲体内铅负担的大约3%保留在哺乳幼崽的窝窝中。中度缺钙的饮食不会增加哺乳期母体骨骼中铅的活化量。哺乳期间母亲持续摄入铅显著增加了铅向哺乳幼崽的净转移。哺乳期铅从母体转移到子代的各处理组均大大超过妊娠期铅的转移。这些数据表明，在评估哺乳婴儿的潜在铅暴露时，应同时考虑以前和现在的母亲铅暴露。
Drinking water containing 200 μg/ml lead (labeled with210Pb) was provided to adult female mice for 105 days prior to the date of mating or for 105 days prior to mating and during the periods of gestation and lactation (160 days total exposure). During lactation there was an increased rate of lead elimination from adult mice exposed prior to mating compared to nonlactating female mice. The magnitude of the additional lead elimination during lactation was similar to the magnitude of the decrease in femur ash weights during lactation. These data support the hypothesis that lead mobilization during lactation is the result of bone mineral mobilization. Approximately 3% of the lead body burden of mothers exposed to lead prior to mating was retained in litters of suckling pups as a result of lead transferred in milk. The magnitude of lead mobilized from maternal bone during lactation was not increased by a diet which was moderately calcium deficient. Continuous ingestion of lead by mothers during lactation significantly increased the net transfer of lead to suckled pups. Lead transferred from mother to offspring during lactation greatly exceeded transfer during gestation for all treatment groups. These data indicate that both prior and current maternal lead exposure should be considered in assessing potential lead exposure of suckling infants.