On the significance of magnesium in extreme physical stress
On the significance of magnesium in extreme physical stress
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DOI：
10.1023/a:1007708918683
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发表时间：
1998-09-01
影响因子：
3.4
通讯作者：
Grüttner, J
中科院分区：
文献类型：
--
作者：
Golf, SW;Bender, S;Grüttner, J
在一项双盲随机研究中，对23名参加500米游泳、20公里自行车比赛和5公里跑步的铁人三项运动员在补充安慰剂或17 mmol/d乳清酸镁4周后进行了研究。试验进行得很顺利。在试验前后和不同事件之间采集血液，用于测定能量应激和膜代谢。与对照组相比，乳清酸镁组的游泳、骑自行车和跑步时间减少。在试验期间，对照组的血清葡萄糖浓度增加了87%，乳清酸镁组增加了118%，而对照组的血清胰岛素增加了39%，乳清酸镁组降低了65%。静脉氧分压增加126%，在对照组和镁乳清酸盐组增加208%。在自行车比赛后，乳清酸镁组的静脉CO2分压下降了66%（显著），而对照组下降了74%。乳清酸镁组的血液质子浓度降低至90%（显著），而对照组为98%。血白细胞计数在对照组中从5.92/nL增加到11.0/nL，在乳清酸镁组中从5.81/nL增加到9.10/nL，具有显著差异。与对照组相比，乳清酸镁组在试验前后血清皮质醇均较低。试验后对照组CK催化浓度比122%乳清酸镁组提高140%。本研究中描述的应激诱导的能量和激素代谢的改变表明，补充乳清酸镁后葡萄糖利用率改变，应激反应降低，而不影响竞争潜力。
In a double-blind randomized study, 23 competitive triathletes competing in an event consisting of a 500-meter swim, a 20-km bicycle race, and a 5-km run were studied after 4-week supplementation with placebo or 17 mmol/d Mg orotate. The tests were carried out without a break. Blood was collected before and after the test, and between the different events for assaying energy stress and membrane metabolism. Swimming, cycling, and running times decreased in the Mg-orotate group compared with the controls. Serum glucose concentration increased 87% during the test in the control group and 118% in the Mg-orotate group, while serum insulin increased 39% in the controls and decreased 65% in the Mg-orotate group. Venous O-2 partial pressure increased 126% during the test in the controls and increased 208% in the Mg-orotate group. Venous CO2 partial pressure after the bicycle race decreased 66% (significantly) in the Mg-orotate group compared with 74% in the controls. Blood proton concentration decreased to 90% in the Mg-orotate group (significantly) compared with 98% in the controls. Blood leukocyte count increased from 5.92/nL to 11.0/nL in the controls and from 5.81/nL to 9.10/nL in the Mg-orotate group, a significant difference. Serum cortisol was lower in the Mg-orotate group before and after the test compared with the controls. CK catalytic concentration after the test was elevated 140% in the controls compared with 122% Mg-orotate group. The stress-induced modifications of energy and hormone metabolism described in this study indicate altered glucose utilization after Mg-orotate supplementation and a reduced stress response without affecting competitive potential.