Measurement of histamine metabolites in brain and cerebrospinal fluid provides insights into histaminergic activity.
Measurement of histamine metabolites in brain and cerebrospinal fluid provides insights into histaminergic activity.
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测量大脑和脑脊液中的组胺代谢物可以深入了解组胺能活性。
DOI：
10.1007/bf02007743
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Green,JP
中科院分区：
文献类型：
--
作者：
Prell,GD;Green,JP
脑中组胺代谢物远甲基组胺（t-MH）和远甲基咪唑乙酸（t-MIAA）浓度的测量已用于评估动物脑中组胺的转换，CSF中相同的测量已用于推断人脑中的组胺能活动。在大鼠脑区，组胺的半衰期比多巴胺、5-羟色胺和去甲肾上腺素的半衰期短。对人CSF的研究表明，脑组胺能活性随年龄增长而增加，女性高于男性。
Measurements of the concentrations of histamine's metabolites,tele-methylhistamine (t-MH) andtele-methylimidazoleacetic acid (t-MIAA), in brain have been used to evaluate histamine turnover in brains of animals, and the same measurements in CSF have been used to infer histaminergic activity in brains of man. In regions of rat brain, half-lives of histamine are shorter than those of dopamine, 5-hydroxytryptamine and norepinephrine. Studies of human CSF suggest that brain histaminergic activity increases with age and is higher in females than in males.