Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus
Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus
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DOI：
10.1615/critreveukaryotgeneexpr.2017019712
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发表时间：
2017-01-01
影响因子：
1.6
通讯作者：
Rasul, Akhtar
中科院分区：
文献类型：
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作者：
Rehman, Kanwal;Akash, Muhammad Sajid Hamid;Rasul, Akhtar
白细胞介素-6（IL-6）是一种促炎细胞因子，其通过控制分化、迁移、增殖和细胞凋亡产生炎症，决定性地诱导胰岛素抵抗的发展和2型糖尿病（T2 DM）的发病机制。组织中存在IL-6是正常的结果，但其不规则的产生和长期暴露会导致炎症的发展，从而诱导胰岛素抵抗和明显的T2 DM。IL-6的刺激与胰岛素抵抗之间存在机制关系。IL-6通过诱导SOCS-3（一种潜在的胰岛素信号传导抑制剂）的表达，损害胰岛素受体和胰岛素受体底物-1的磷酸化，从而引起胰岛素抵抗。本文就IL-6如何诱导胰岛素抵抗及T2 DM的发病机制作一综述。通过阻断IL-6和IL-6信号通路来预防炎症性疾病可能是治疗胰岛素抵抗和T2 DM的有效策略。
Interleukin-6 (IL-6) is a proinflammatory cytokine that decisively induces the development of insulin resistance and pathogenesis of type 2 diabetes mellitus (T2DM) through the generation of inflammation by controlling differentiation, migration, proliferation, and cell apoptosis. The presence of IL-6 in tissues is a normal consequence, but its irregular production and long-term exposure leads to the development of inflammation, which induces insulin resistance and overt T2DM. There is a mechanistic relationship between the stimulation of IL-6 and insulin resistance. IL-6 causes insulin resistance by impairing the phosphorylation of insulin receptor and insulin receptor substrate-1 by inducing the expression of SOCS-3, a potential inhibitor of insulin signaling. In this article, we have briefly described how IL-6 induces the insulin resistance and pathogenesis of T2DM. The prevention of inflammatory disorders by blocking IL-6 and IL-6 signaling may be an effective strategy for the treatment of insulin resistance and T2DM.