The carbonic anhydrase inhibitor in serum
The carbonic anhydrase inhibitor in serum
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血清碳酸酐酶抑制剂
DOI：
10.1113/jphysiol.1938.sp003574
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发表时间：
1938
期刊：
影响因子：
--
通讯作者：
V. H. Booth
中科院分区：
文献类型：
--
作者：
V. H. Booth
在猪和其他哺乳动物血清中发现的一种碳酸酐酶活性抑制剂，在最近的一份说明中进行了简要描述[Booth，1936]。碳酸酐酶通常仅存在于小体中，血浆中不存在碳酸酐酶在体内血液pH值调节方面具有明显优势[劳顿，1935]。抑制剂的功能被认为是保护性的，因为它提供了一种临时机制，以确保由于血球破坏而可能释放到循环血浆中的任何碳酸酐酶不会取消这些优点。当发现抑制剂不存在于人的血液中时，这一建议的大部分力量就丧失了，然而，尽管血清的抑制活性可能是偶然的，但人们认为研究（a）抑制剂与酶的动力学关系，（B）其自身的化学性质，以及（c）其分布是有意义的。
AN active inhibitor of carbonic anhydrase found in the sera of pig and other mammals, was briefly described in a recent note [Booth, 1936]. Carbonic anhydrase is normally found only in corpuscles, and its absence from the plasma has distinct advantages in the regulation of the blood pH in vivo [Roughton, 1935]. The function of the inhibitor was thought to be a protective one in that it provides a temporary mechanism for ensuring that any carbonic anhydrase which may be set free into the circulating plasma as a result of corpuscle destruction does not annul these advantages. Much of the force of this suggestion was lost on finding that the inhibitor is not present in the blood of man. However, even though the inhibitory activity of serum may be accidental it was considered of interest to study (a) the kinetic relations of the inhibitor to the enzyme, (b) its own chemical nature, and (c) its distribution.