The Use of Soluble Transferrin Receptor in the Detection of rHuEPO abuse in Sports
The Use of Soluble Transferrin Receptor in the Detection of rHuEPO abuse in Sports
复制标题
使用可溶性转铁蛋白受体检测运动中 rHuEPO 滥用
DOI：
10.4137/bci.s3943
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发表时间：
2010
影响因子：
--
通讯作者：
L. Gordon
中科院分区：
文献类型：
--
作者：
D. McGrowder;P. Brown;R. Alexander;Shirley Budall;R. Irving;L. Gordon
促红细胞生成素（EPO）增加循环红细胞和肌肉氧合的数量。重组形式的促红细胞生成素被运动员任意使用，主要是在耐力运动中，以增加他们的红细胞浓度，从而产生更好的氧气输送到肌肉组织。重组人促红细胞生成素（rHuEPO）除治疗用途外被国际奥委会（IOC）禁止使用，其未经授权的使用被视为兴奋剂。在过去的几年中，一些使用促红细胞生成加速参数的研究调查了一些间接检测促红细胞生成素滥用的方法。没有发现单一的间接标记可以令人满意地证明rHuEPO误用。可溶性转铁蛋白受体（sTfR）是一种新的铁状态和红细胞生成活性的标志物。它已被纳入多变量血液检测模型，用于检测运动中滥用促生成素的表现。红细胞生成改变的间接标记物提供了目前或已停止使用rHuEPO的可靠证据。本文综述了内源性EPO及其重组形式的物理、生物学和药代动力学特性。它还讨论了在体育运动中检测rHuEPO滥用的可用策略，包括直接使用sTfR浓度或在数学多元模型中使用。
Erythropoietin (EPO) increases the number of circulating erythrocytes and muscle oxygenation. The recombinant forms of EPO have indiscriminately been used by athletes, mainly in endurance sports to increase their erythrocytes concentration, thus generating a better delivery of oxygen to the muscle tissue. The administration of recombinant human erythropoietin (rHuEPO) except for therapeutic use was prohibited by the International Olympic Committee (IOC) and its unauthorized use considered as doping. In the last few years, a number of studies using parameters indicative of accelerated erythropoiesis have investigated a number of indirect methods for the detection of rHuEPO abuse. No single indirect marker has been found that can satisfactorily demonstrated rHuEPO misuse. Soluble transferrin receptor (sTfR) is a new marker of iron status and erythropoietic activity. It has been included in multivariable blood testing models for the detection of performance enhancing EPO abuse in sports. Indirect markers of altered erythropoiesis give reliable evidence of current or discontinued rHuEPO usage. This review describes the physical, biological and pharmacokinetic properties of endogenous EPO and its recombinant form. It also discusses the available strategies for the detection of rHuEPO abuse in sports, involving the use of sTfR concentration directly or in mathematical multivariate models.
影响因子：
20.3
作者：
Chris P. Miller;Destin W. Heilman;D. Wojchowski
通讯作者：
Chris P. Miller;Destin W. Heilman;D. Wojchowski
影响因子：
6.9
作者：
Tussing-Humphreys, Lisa M.;Nemeth, Elizabeta;Braunschweig, Carol
通讯作者：
Braunschweig, Carol