Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Acute Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Acute Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
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DOI：
10.1097/mpa.0000000000001175
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发表时间：
2018
期刊：
影响因子：
2.9
通讯作者：
Wu BU
中科院分区：
文献类型：
--
作者：
Abu-El-Haija M;Gukovskaya AS;Andersen DK;Gardner TB;Hegyi P;Pandol SJ;Papachristou GI;Saluja AK;Singh VK;Uc A;Wu BU
国家糖尿病、消化和肾脏疾病研究所主办了一个讲习班，重点讨论胰腺炎药物开发的研究差距和机会。本次会议于2018年7月25日举行，分为3个工作组（WG）：急性胰腺炎（AP）WG，复发性AP WG和慢性胰腺炎WG。本文报告了AP WG完成的工作成果，以提供AP的自然史，流行病学和当前管理;告知临床前模型在治疗选择中的作用;并讨论临床试验设计与临床和患者报告的结果，以测试新疗法。
A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities on drug development for pancreatitis. This conference was held on July 25, 2018, and structured into 3 working groups (WG): acute pancreatitis (AP) WG, recurrent AP WG, and chronic pancreatitis WG. This article reports the outcome of the work accomplished by the AP WG to provide the natural history, epidemiology, and current management of AP; inform about the role of preclinical models in therapy selection; and discuss clinical trial designs with clinical and patient-reported outcomes to test new therapies.