Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis
Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis
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DOI：
10.1016/j.jns.2004.02.008
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发表时间：
2004-05-15
影响因子：
4.4
通讯作者：
Heo, JH
中科院分区：
文献类型：
--
作者：
Lee, KY;Kim, EH;Heo, JH
采用明胶酶谱法和酶联免疫吸附试验（ELISA）检测了24例结核性脑膜炎（n=24）、23例急性无菌性脑膜炎（n=23）和10例正常对照组脑脊液（CSF）中基质金属蛋白酶（MMP）-2和MMP-9的含量。结核性脑膜炎患者血清中MMP-2和MMP-9水平显著高于无菌性脑膜炎患者和对照组。在结核性脑膜炎中，有晚期神经系统并发症的患者MMP-2和MMP-9水平高于无神经系统并发症的患者。MMP-2和MMP-9水平的持续升高与结核性脑膜炎并发症的发生有关。抑制MMPs可能是预防或减少结核性脑膜炎并发症的有效策略。(C)2004 Elsevier B. V.保留所有权利。
Matrix metalloproteinase (MMP)-2 and MMP-9 were analyzed by gelatin zymography and an enzyme-linked immunosorbent assay (ELISA) in a cerebrospinal fluid (CSF) from patients with tuberculous meningitis (n=24), acute aseptic meningitis (n=23) and the control (n=10). The MMP-2 and MMP-9 levels were significantly higher in the samples from the tuberculous meningitis patients than those from either the aseptic meningitis patients or the controls. In tuberculous meningitis, the patients with late neurologic complications had higher MMP-2 and MMP-9 levels than those without. The persistent increase in the MMP-2 and MMP-9 levels was associated with the development of complications following tuberculous meningitis. Inhibiting the MMPs may be an effective strategy for preventing or reducing the complications in tuberculous meningitis. (C) 2004 Elsevier B.V. All rights reserved.