Saturated and trans fats and dementia: a systematic review
Saturated and trans fats and dementia: a systematic review
复制标题
DOI：
10.1016/j.neurobiolaging.2014.02.030
复制
发表时间：
2014-09-01
影响因子：
4.2
通讯作者：
Agarwal, Ulka
中科院分区：
文献类型：
--
作者：
Barnard, Neal D.;Bunner, Anne E.;Agarwal, Ulka
晚年的认知障碍可能是毁灭性的。评估饱和脂肪和反式脂肪摄入与认知障碍风险之间的关系。PubMed、EMBASE和Cochrane中央对照试验登记中心检索了饱和脂肪或反式脂肪摄入与痴呆、阿尔茨海默病（AD）、轻度认知障碍（MCI）或认知能力下降有关的研究。只有观察性研究符合纳入标准：4项针对AD或其他痴呆，4项针对MCI， 4项针对认知能力下降。在4项研究中，有3项研究表明饱和脂肪摄入量与AD风险呈正相关，而第4项研究则表明两者呈负相关。在2项研究中，1项研究发现饱和脂肪摄入与痴呆总量呈正相关；在4项研究中，1项研究发现饱和脂肪摄入与轻度认知障碍呈正相关；在4项研究中，2项研究发现饱和脂肪摄入与认知能力下降呈正相关。反式脂肪摄入与痴呆之间的关系在3份报告中得到了不同的结果。一些（尽管不是全部）前瞻性研究表明饱和脂肪和反式脂肪摄入与认知障碍风险之间存在关系。(C) 2014年作者。Elsevier Inc.出版。版权所有。
Cognitive disorders of later life are potentially devastating. To estimate the relationship between saturated and trans fat intake and risk of cognitive disorders. PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for studies reporting saturated or trans fat intake and incident dementia, Alzheimer's disease (AD), or mild cognitive impairment (MCI) or cognitive decline. Only observational studies met the inclusion criteria: 4 for AD or other dementias, 4 for MCI, and 4 for cognitive decline. Saturated fat intake was positively associated with AD risk in 3 of 4 studies, whereas the fourth suggested an inverse relationship. Saturated fat intake was also positively associated with total dementia in 1 of 2 studies, with MCI in 1 of 4 studies, and with cognitive decline in 2 of 4 studies. Relationships between trans fat intake and dementia were examined in 3 reports with mixed results. Several, although not all, prospective studies indicate relationships between saturated and trans fat intake and risk of cognitive disorders. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.