ASSOCIATION BETWEEN DIETARY IODINE INTAKE AND PREVALENCE OF SUBCLINICAL HYPOTHYROIDISM IN THE COASTAL REGIONS OF JAPAN
ASSOCIATION BETWEEN DIETARY IODINE INTAKE AND PREVALENCE OF SUBCLINICAL HYPOTHYROIDISM IN THE COASTAL REGIONS OF JAPAN
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DOI：
10.1210/jc.78.2.393
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发表时间：
1994-02-01
影响因子：
5.8
通讯作者：
KAWASAKI, K
中科院分区：
文献类型：
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作者：
KONNO, N;MAKITA, H;KAWASAKI, K
甲状腺功能障碍的患病率与碘的摄入量进行了研究，在成人（n = 1061）在日本的五个沿海地区，生产富碘海藻（海带）。甲状腺功能亢进症（TSH < 0.15 mU/L）的患病率在这些地区相似，而甲状腺功能减退症（TSH > 5.0 mU/L）的患病率在0- 9.7%之间。晨尿碘浓度高于正常值（大于或等于75 μ mol/L）[高尿碘（UI）]的相对频率为3.7%-30.3%。结合非沿海城市的研究结果，高UI与甲状腺自身抗体阴性的甲减（r = 0.829，n = 6，P < 0.05）相关，而与甲状腺自身抗体阳性（r = 0.278，NS）或甲状腺功能亢进（r = 0.038，NS）无关。
The prevalence of thyroid dysfunction in relation to iodine intake was studied in adults (n = 1061) in five coastal areas of Japan that produce iodine-rich seaweed (kelp). The prevalence of hyperthyroidism (TSH < 0.15 mU/L) was similar in these areas, whereas that of hypothyroidism (TSH > 5.0 mU/L) varied from 0-9.7%. The relative frequency of above normal iodide concentration in the morning urine (greater than or equal to 75 mu mol/L) [high urinary iodide (UI)] varied from 3.7%-30.3%. Together with previously reported results of a noncoastal city, the frequency of high UI correlated significantly with that of hypothyroidism with negative thyroid autoantibody (r = 0.829, n = 6, P < 0.05) but not with positive thyroid autoantibody (r = 0.278, NS) or with that of hyperthyroidism (r = 0.038, NS).