SR-BI selective lipid uptake: subsequent metabolism of acute phase HDL.
SR-BI selective lipid uptake: subsequent metabolism of acute phase HDL.
复制标题
SR-BI选择性脂质摄取：急性期HDL的随后代谢。
DOI：
10.1161/atvbaha.109.186502
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
de Beer FC
中科院分区：
文献类型：
--
作者：
de Beer MC;Webb NR;Whitaker NL;Wroblewski JM;Jahangiri A;van der Westhuyzen DR;de Beer FC
To investigate the interaction of SAA and SR-BI in remodeling of acute phase HDL (AP HDL). We used SAA and SR-BI adenoviral vector expression models to study the interaction between these entities. SR-BI processing of mouse AP HDL generated progressively smaller discreet HDL particles with distinct apolipoprotein compositions. SR-BI actions segregated apolipoproteins with the smallest particles containing only apoA-I. Larger remnants contained apoA-I, apoA-II and SAA. Small apoA-I only particles failed to associate with preformed HDL whereas larger remnants readily did. The presence of SAA on SR-BI processed HDL particles propelled apoA-I to a small lipid-poor form and accelerated apoA-I catabolism. Data indicate that after core and surface HDL lipid perturbation by SR-BI, SAA propels apoA-I to a small lipid-poor form while accelerating HDL metabolism.
