Retrovirus-associated Ovine Pulmonary Carcinoma (Sheep Pulmonary Adenomatosis) and Lymphoid Interstitial Pneumonia. I. Lesion Development and Age Susceptibility
Retrovirus-associated Ovine Pulmonary Carcinoma (Sheep Pulmonary Adenomatosis) and Lymphoid Interstitial Pneumonia. I. Lesion Development and Age Susceptibility
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逆转录病毒相关的绵羊肺癌（绵羊肺腺瘤病）和淋巴样间质性肺炎。
DOI：
10.1177/030098588802500611
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发表时间：
1988
影响因子：
2.4
通讯作者：
J. Demartini
中科院分区：
文献类型：
--
作者：
R. Rosadio;M. Lairmore;H. Russell;J. Demartini
To determine the lesion development of retrovirus-induced ovine pulmonary carcinoma (OPC), ten neonatal lambs were inoculated intratracheally with either 1) lung fluid preparations derived from a sheep with Type D retrovirus-associated OPC and concurrent ovine lentivirus (OvLV)-associated lymphoid interstitial pneumonia (LIP) (n = 8); or 2) lung fluid from a sheep with only OvLV-LIP (n = 2). Seven of eight neonates that received Type D retrovirus-associated OPC/OvLV-LIP lung fluid developed both OPC and LIP lesions between 9 and 32 weeks after inoculation. Mild OPC lesions consisted of foci of type II alveolar epithelial cells lining alveoli surrounded by minimal alveolar macrophage infiltrates. More severe OPC lesions consisted of multifocal aggregates of cuboidal to columnar neoplastic cells forming acini or masses associated with abundant alveolar macrophage infiltrates. Lesions of LIP consisted of peribronchiolar and perivascular lymphoid hyperplasia and heterogeneous interstitial leukocytic infiltrates. The two neonates that received OvLV-LIP lung fluid developed rapid and severe LIP, but not OPC lesions. Two lambs (inoculated as neonates with virus-free lung fluid) and three lambs (uninoculated contacts) served as controls and did not develop OPC. To investigate age susceptibility for development of OPC, 20 additional lambs within defined age groups (neonates, 2 weeks old, 5 weeks old, and 10 weeks old) received ultracentrifuged tumor homogenate. Neonatal to 5-week-old lambs inoculated with Type D retrovirus-associated OPC/OvLV-LIP tumor homogenate were equally likely to develop OPC, but lambs inoculated at 10 weeks of age were more refractory to tumor development. These results suggest that infection of sheep by the OPC retrovirus early in life enhances susceptibility to pulmonary neoplasia and defines methods to optimize experimental reproduction of this retrovirus-induced carcinoma.
DOI：
--
发表时间：
1983
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Wheelock,EF;Robinson,MK
通讯作者：
Robinson,MK
山羊关节炎脑炎病毒的传播和控制。
影响因子：
1
作者：
Adams,DS;Klevjer-Anderson,P;Carlson,JL;McGuire,TC;Gorham,JR
通讯作者：
Gorham,JR