Malignant hyperthermia (MH) diagnostics: a comparison between the halothane‐caffeine‐and the ryanodine‐contracture‐test results in MH susceptible, normal and control muscle
Malignant hyperthermia (MH) diagnostics: a comparison between the halothane‐caffeine‐and the ryanodine‐contracture‐test results in MH susceptible, normal and control muscle
复制标题
恶性高热 (MH) 诊断：MH 易感、正常和对照肌肉中氟烷咖啡因和兰尼丁挛缩测试结果的比较
DOI：
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发表时间：
1996
影响因子：
2.1
通讯作者：
W. Engelhardt
中科院分区：
文献类型：
--
作者：
E. Hartung;M. Koob;M. Anetseder;P. Schömig;R. Krauspe;G. Hogrefe;W. Engelhardt
Recent studies demonstrated different contracture responses in muscle from malignant hyperthermia susceptible (MHS) compared to normal (MHN) individuals following exposure to the plant alkaloid ryanodine in‐vitro. To confirm if ryanodine has a specific action in MHS muscle, the effect of a single concentration was investigated in skeletal muscle from MHS, MHN and control subjects using a new evaluation technique. In‐vitro contracture test (IVCT) and MH diagnosis were performed according to the European Protocol in 86 patients sent to us for MH diagnostic testing and in 24 controls. Viable fresh muscle bundles were exposed to a single bolus of ryanodine 1.0 μM. Contracture onset time (OTp: defined as the time (min) from administration of ryanodine to the start of a contracture as measured by a contracture exceeding predrug baseline height), and the time to an increase of the baseline height to 10 mN above the predrug level (10Tp) were recorded.
DOI：
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发表时间：
1988
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Mickelson,JR;Gallant,EM;Litterer,LA;Johnson,KM;Rempel,WE;Louis,CF
通讯作者：
Louis,CF
从恶性高热易感猪肌肉中分离出的肌浆网囊泡增强了 Ca2 诱导的钙释放。
DOI：
10.1016/0005-2736(86)90234-8
发表时间：
1986
期刊：
Biochimica et biophysica acta
影响因子：
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作者：
Mickelson,JR;Ross,JA;Reed,BK;Louis,CF
通讯作者：
Louis,CF