INTERLEUKIN-6 IS THE MAJOR REGULATOR OF ACUTE PHASE PROTEIN-SYNTHESIS IN ADULT HUMAN HEPATOCYTES
INTERLEUKIN-6 IS THE MAJOR REGULATOR OF ACUTE PHASE PROTEIN-SYNTHESIS IN ADULT HUMAN HEPATOCYTES
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DOI：
10.1016/0014-5793(89)80476-4
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发表时间：
1989-01-02
期刊：
影响因子：
3.5
通讯作者：
HEINRICH, PC
中科院分区：
文献类型：
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作者：
CASTELL, JV;GOMEZLECHON, MJ;HEINRICH, PC
白介素1β(IL-1β)、肿瘤坏死因子α(肿瘤坏死因子α)和白介素6(IL-6)三种单因子对成人肝细胞急性期血浆蛋白合成有调节作用。在炎症状态下，只有IL-6刺激全谱急性时相蛋白的合成，即C反应蛋白、血清淀粉样蛋白A、纤维蛋白原、α1抗胰蛋白酶、α1抗糜蛋白酶和结合珠蛋白的合成和分泌增加，而白蛋白、转铁蛋白和纤维连接蛋白减少。IL-1β和肿瘤坏死因子α虽然对急性时相阳性蛋白有温和作用，抑制纤维蛋白原、白蛋白和转铁蛋白的合成，但不能诱导血清淀粉样蛋白A和C反应蛋白。这些数据表明，IL-6在人肝细胞急性期蛋白质合成的调节中起关键作用。
The three monokines interleukin‐1β (IL‐1β), tumor necrosis factor α (TNFα), and interleukin‐6 (IL‐6) modulate acute phase plasma protein synthesis in adult human hepatocytes. Only IL‐6 stimulates the synthesis of the full spectrum of acute phase proteins as seen in inflammatory states in humans, i.e. synthesis and secretion of C‐reactive protein, serum amyloid A, fibrinogen, α1‐antitrypsin, α1‐antichymotrypsin and haptoglobin are increased while albumin, transferrin and fibronectin are decreased. IL‐1β as well as TNFα, although having a moderate effect on the positive acute phase proteins and inhibiting the synthesis of fibrinogen, albumin and transferrin, fail to induce serum amyloid A and C‐reactive protein. These data suggest that IL‐6 plays the key role in the regulation of acute phase protein synthesis in human hepatocytes.