Updated scalp heuristics for localizing the dorsolateral prefrontal cortex based on convergent evidence of lesion and brain stimulation studies in depression
Updated scalp heuristics for localizing the dorsolateral prefrontal cortex based on convergent evidence of lesion and brain stimulation studies in depression
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DOI：
10.1016/j.brs.2022.01.013
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发表时间：
2022-02-04
影响因子：
7.7
通讯作者：
Downar, Jonathan
中科院分区：
文献类型：
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作者：
Mir-Moghtadaei, Arsalan;Siddiqi, Shan H.;Downar, Jonathan
背景：重复经颅磁刺激（rTMS）作为许多精神疾病的治疗干预手段正得到越来越广泛的应用。这种治疗干预的有效性可能取决于准确定位靶脑区域。最近研究与抑郁症相关的全脑回路图及其成功治疗的工作已经确定了背外侧前额叶皮层（DLPFC）内的兴趣焦点。目的：基于损伤证据和脑刺激研究，建立一种更新的DLPFC定位头皮启发式方法。方法：使用标准的MNI ICBM152解剖模板，将头皮定位在距离目标MNI坐标最小欧氏距离处，并在解剖模板上进行鼻窦、耳垂和头围测量。然后我们推导出方程式来定位这些头皮部位。结果：计算新目标的弧长X和Y的导出方程为：[Y = (NI + TrTr)/2) X 0.3167；X = HC X 0.1359]左前DLPFC[Y = ((NI + TrTr)/2) X 0.2884；X = HC X 0.1352]右前DLPFC[Y = ((NI + TrTr)/2) X 0.2480；X = HC X 0.1847]为左后侧DLPFC[Y = (NI + TrTr)/2) X 0.2316；结论：这种启发式方法可能有助于定位在先前病变/刺激映射工作中确定的DLPFC靶点。提供了一个电子表格计算工具来支持这种启发式的使用。(C) 2022作者。Elsevier Inc.出版。
Background: Repetitive transcranial magnetic stimulation (rTMS) is entering wider use as a therapeutic intervention for many psychiatric illnesses. The efficacy of this therapeutic intervention may depend on accurately localizing target brain regions. Recent work investigating whole-brain maps of circuits associated with depression and its successful treatment has identified foci of interest within the dorsolateral prefrontal cortex (DLPFC).Objective: To create an updated scalp heuristic for localizing the DLPFC based on convergent evidence of lesion and brain stimulation studies in depression.Methods: Using the standard MNI ICBM152 anatomical template, we localized the scalp sites at minimum Euclidean distance from target MNI coordinates and performed nasion-inion, tragus-tragus, and head-circumference measurements on the anatomical template. We then derived equations to localize these scalp sites.Results: The derived equations to calculate the arc length X and Y for these new targets are as follows: [Y = ((NI + TrTr)/2) x 0.3167 ; X = HC x 0.1359] for the left anterior DLPFC[Y = ((NI + TrTr)/2) x 0.2884; X = HC x 0.1352] for the right anterior DLPFC[Y = ((NI + TrTr)/2) x 0.2480; X = HC x 0.1847] for the left posterior DLPFC[Y = ((NI + TrTr)/2) x 0.2316 ; X = HC x 0.1968] for the right posterior DLPFCConclusions: This heuristic may help localize DLPFC targets identified in previous lesion-/stimulation-mapping work. A spreadsheet calculation tool is offered to support use of this heuristic. (C) 2022 The Authors. Published by Elsevier Inc.