Bioactive neolignans from Endlicheria dysodantha.
Bioactive neolignans from Endlicheria dysodantha.
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DOI：
10.1021/np50076a045
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发表时间：
1991-07
影响因子：
5.1
通讯作者：
W. Ma;J. Kozlowski;J. McLaughlin
中科院分区：
文献类型：
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作者：
W. Ma;J. Kozlowski;J. McLaughlin
通过生物活性定向分馏，分离得到了新的六氢苯并呋喃类新木质素A和B。此外，还分离出了已知的新木脂素、化合物4（一种波氏菌素类似物）和醋酸扩音器[1]。4种新木脂素在盐水对虾致死试验中均有活性；化合物1 ~ 3还能抑制马铃薯盘上冠瘿瘤的生长，并对培养的人肿瘤细胞具有细胞毒性。这是第一次从Endlicheria属中分离到这些新木脂属植物，并获得了完整的1h和13c核磁共振数据。
From bioactivity-directed fractionation of the EtOH extract of Endlicheria dysodantha, dysodanthin A and dysodanthin B, which are new hexahydrobenzofuranoid neolignans, have been isolated. In addition, the known neolignans, compound 4, which is a burchellin analogue, and megaphone acetate [1] were isolated. All four neolignans showed activities in the brine shrimp lethality test; compounds 1-3 also inhibited the growth of crown gall tumors on potato discs and were cytotoxic to human tumor cells in culture. This is the first report of these neolignans isolated from the genus Endlicheria and of their completely assigned 1H-and 13C-nmr data.