EFFECTS OF DRUG EXPERIENCE ON DRUG-INDUCED CONDITIONED TASTE AVERSIONS - STUDIES WITH AMPHETAMINE AND FENFLURAMINE
EFFECTS OF DRUG EXPERIENCE ON DRUG-INDUCED CONDITIONED TASTE AVERSIONS - STUDIES WITH AMPHETAMINE AND FENFLURAMINE
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DOI：
10.1007/bf00421187
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
THORNTON, EW
中科院分区：
文献类型：
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作者：
GOUDIE, AJ;THORNTON, EW
大鼠腹腔注射盐酸芬氟拉明（6 mg/kg）或硫酸苯丙胺（2.0mg/kg）对0.1%糖精钠产生条件性味觉厌恶（C. T. As），慢性预处理（9天以上）可明显减弱，但不能完全消除。先前用芬氟拉明治疗减弱了安非他明的厌恶作用，但发现匡威并非如此。这些结果被认为是反驳了“非自然需求状态”和“新奇”假设的影响，以前的药物经验的建立C.T.A.另一种解释，这种影响的耐受性被认为是，并讨论了可能的相关性的结果，在人类药物滥用的研究。
Conditioned taste aversions (C.T.As) established in rats to 0.1% sodium saccharin by intra-peritoneal injections ofdl-fenfluramine hydrochloride (6 mg per kg) ord-amphetamine sulphate (2.0 mg per kg) were found to be significantly attenuated, but not abolished altogether, by chronic pretreatment (over 9 days) with the specific drug. Prior treatment with fenfluramine attenuated the aversive effects of amphetamine, but the converse was foundnotto be the case. These results are considered to refute the “Unnatural need state” and “Novelty” hypotheses of the effects of prior drug experience on the establishment of C.T.As. An alternative explanation of such effects in terms of tolerance is considered, and the possible relevance of the results to studies of drug abuse in humans discussed.