Stereocontrolled Total Synthesis of Hedyotol A
Stereocontrolled Total Synthesis of Hedyotol A
复制标题
姜黄醇A的立体控制全合成
DOI：
10.1021/ol500524y
复制
发表时间：
2014
期刊：
影响因子：
5.2
通讯作者：
Yoshitaka Hamashima and Toshiyuki Kan
中科院分区：
文献类型：
--
作者：
Yusuke Kawabe;Ryo Ishikawa;Yusuke Akao;Atsushi Yoshida;Makoto Inai;Tomohiro Asakawa;Yoshitaka Hamashima and Toshiyuki Kan
从毛耳草（Hedyotis lawsoniae（DC.）怀特阿恩（茜草科），是在一个高度立体控制的方式完成。关键步骤包括脯氨酸催化的交叉羟醛反应和通过醌甲基中间体仿生构建呋喃木脂素骨架。
The total synthesis of hedyotol A (1), a natural product isolated fromHedyotis lawsoniae(DC.) WightetArn. (Rubiaceae), was accomplished in a highly stereocontrolled manner. Key steps include anl-proline-catalyzed cross-aldol reaction and the biomimetic construction of a furofuran lignan skeleton through a quinomethide intermediate.