Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization
Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization
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DOI：
10.1006/dbio.2000.9957
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发表时间：
2001-02-15
影响因子：
2.7
通讯作者：
Anderson, DJ
中科院分区：
文献类型：
--
作者：
Shin, D;Garcia-Cardena, G;Anderson, DJ
跨膜配体ephrinB2及其受体酪氨酸激酶EphB4分别是胚胎动脉和静脉内皮细胞的分子标志物，并且对于血管生成是必需的。在这里，我们发现ephrinB2的表达持续在成人动脉中，它延伸到一些最小直径的微血管，挑战经典的观点，毛细血管既没有动脉也没有静脉的身份。EphrinB2还在成人新血管形成的几种情况下识别动脉微血管，包括肿瘤血管生成，违反了肿瘤血管完全来自毛细血管后小静脉的教条。出乎意料的是，ephrinB2的表达也定义了动脉和静脉血管平滑肌细胞之间稳定的遗传差异。这些意见认为，毛细血管身份和地形的经典概念的修订新血管。他们还暗示ephrinB2可能在新生血管形成和动脉平滑肌以及胚胎血管生成中具有重要功能。(C)北京：科学出版社.
The transmembrane ligand ephrinB2 and its receptor tyrosine kinase EphB4 are molecular markers of embryonic arterial and venous endothelial cells, respectively, and are essential for angiogenesis. Here we show that expression of ephrinB2 persists in adult arteries where it extends into some of the smallest diameter microvessels, challenging the classical view that capillaries have neither arterial nor venous identity. EphrinB2 also identifies arterial microvessels in several settings of adult neovascularization, including tumor angiogenesis, contravening the dogma that tumor vessels arise exclusively from postcapillary venules. Unexpectedly, expression of ephrinB2 also defines a stable genetic difference between arterial and venous vascular smooth muscle cells. These observations argue for revisions of classical concepts of capillary identity and the topography of neovascularization. They also imply that ephrinB2 may be functionally important in neovascularization and in arterial smooth muscle, as well as in embryonic angiogenesis. (C) 2001 Academic Press.