Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity
Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity
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DOI：
10.1177/1470320313510583
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发表时间：
2014-12-01
影响因子：
2.9
通讯作者：
Lafuente, Amalia
中科院分区：
文献类型：
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作者：
Gasso, Patricia;Ritter, Marie A.;Lafuente, Amalia
ABO rs495828多态性最近与血管紧张素转换酶（ACE）抑制剂诱导的高血压和咳嗽风险相关，这可能是由于ACE血浆活性低所致。研究ABO rs495828是否与ACE活性相关。我们还研究了ABO基因型与表型之间的关系，以及ABO表型组间ACE活性的差异。对象和方法：我们对168名受试者进行rs495828基因分型。在所有同意参与研究的次要等位基因纯合子受试者（TT） （n=8）以及年龄和性别匹配的杂合子受试者（GT; n=8）和主要等位基因纯合子受试者（GG; n=8）中测量ACE血浆活性和ABO组织血型。结果：rs495828基因型组间ACE活性无明显变化趋势；然而，多态性与ABO表型显著相关（p=0.007），而ABO表型又与ACE活性相关（p=0.029）。结论：这些结果为ABO-ACE关系的研究提供了新的证据。尽管本文研究的遗传标记可能在某种程度上参与其中，但ABO表型被证明是ACE血浆活性的更好预测因子。
Introduction: ABO rs495828 polymorphism has recently been associated with risk of hypertension and cough induced by angiotensin-converting enzyme (ACE) inhibitors, which could be due to low ACE plasma activity. To study whether ABO rs495828 is associated with ACE activity. The association between ABO genotype and phenotype, and differences in ACE activity between the ABO phenotype groups were also studied.Subjects and methods: We genotyped 168 subjects for rs495828. ACE plasma activity and ABO histo-blood group were measured in all minor allele homozygous subjects (TT) that agreed to participate in the study (n=8) and in age- and gender-matched heterozygous subjects (GT; n=8) and major allele homozygous subjects (GG; n=8).Results: A non-significant trend was found in ACE activity among rs495828 genotype groups; however the polymorphism was significantly associated with ABO phenotype (p=0.007), which in turn was associated with ACE activity (p=0.029).Conclusion: These results provide new evidence for the ABO-ACE relationship. Although the genetic marker studied here may be involved somehow, ABO phenotype is shown to be a better predictor of ACE plasma activity.