Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder
Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder
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DOI：
10.3389/fpsyt.2019.00140
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发表时间：
2019-03-20
影响因子：
4.7
通讯作者：
Cao, Liping
中科院分区：
文献类型：
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作者：
Deng, Wenhao;Zhang, Bin;Cao, Liping
双相情感障碍（BD）的延迟诊断是常见的。然而，使用可靠的神经生物学标记物可以提高双相障碍的诊断有效性。度中心性（DC）就是这样一个潜在的标记物，它使研究人员能够在一些神经精神疾病的早期阶段看到神经网络异常。在本研究中，我们测量了静息状态DC异常和认知缺陷，以识别双相障碍的早期神经生物学标志物。我们招募了23名最近经历过躁狂发作（病程）的双相障碍患者
Delayed diagnosis of bipolar disorder (BD) is common. However, diagnostic validity may be enhanced using reliable neurobiological markers for BD. Degree centrality (DC) is one such potential marker that enables researchers to visualize neuronal network abnormalities in the early stages of some neuropsychiatric disorders. In the present study, we measured resting-state DC abnormalities and cognitive deficits in order to identify early neurobiological markers for BD. We recruited 23 patients with BD who had recently experienced manic episodes (duration of illness