Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa
Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa
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DOI：
10.1021/ol036239c
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发表时间：
2004-03-18
期刊：
影响因子：
5.2
通讯作者：
Yoshikawa, M
中科院分区：
文献类型：
--
作者：
Morikawa, T;Xu, FM;Yoshikawa, M
从黑种草子中分得4个新的dolabellane型二萜生物碱：黑种草胺A（1）（1），A（2）（2），B-1（3），B-2（4）。根据化学和物理化学证据确定了它们的绝对立体结构。发现黑种草素A（1）、B（3）和B2（4）在原代培养的小鼠肝细胞中显示出有效的脂质代谢促进活性，并且它们的活性与PPAR-alpha激动剂氯贝特的活性相当。
Four new dolabellane-type diterpene alkaloids, nigellamines A(1) (1), A(2) (2), B-1 (3), and B-2 (4), were isolated from the seeds of Nigella sativa. Their absolute stereostructures were determined on the basis of chemical and physicochemical evidence. Nigellamines A, (1), B, (3), and B2 (4) were found to show potent lipid metabolism promoting activity in primary cultured mouse hepatocytes, and their activities were equivalent to that of a PPAR-alpha agonist, clofibrate.