Prior morphine exposure enhances ibogaine antagonism of morphine-induced locomotor stimulation.
Prior morphine exposure enhances ibogaine antagonism of morphine-induced locomotor stimulation.
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先前的吗啡暴露增强了伊博加因对吗啡诱导的运动刺激的拮抗作用。
DOI：
10.1007/bf02246495
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发表时间：
1995
影响因子：
3.4
通讯作者：
Glick,SD
中科院分区：
文献类型：
--
作者：
Pearl,SM;Johnson,DW;Glick,SD
伊博甘目前正在研究其作为抗成瘾剂的潜在用途。在目前的研究中，我们试图确定先前的吗啡暴露是否影响伊博加因抑制吗啡诱导的运动刺激的能力。雌性SD大鼠用吗啡(5，10，20，30 mg/kg，ip)或生理盐水预处理1~4d，然后在末次吗啡预处理后5h再给予伊波金(40 mg/kg，ip)。与生理盐水组相比，吗啡(10、20、30 mg/kg，ip)后再ip(40 mg/kg，ip)的大鼠在给药19h后，对吗啡(5 mg/kg，ip)诱发的运动刺激有明显的抑制作用。此外，这种影响在一定剂量的伊波甘(5-60 mg/kg，ip)和吗啡试验(2.5-5 mg/kg，ip)范围内明显。单独静注5和10 mg/kg剂量的ibogaine可抑制吗啡诱导的大鼠运动活动。这些结果表明，吗啡预暴露影响ibogaine的活性，这表明阿片类药物暴露的不同历史可能解释了ibogaine抑制阿片成瘾效果的个体差异。
Ibogaine is currently being investigated for its potential use as an anti-addictive agent. In the present study we sought to determine whether prior morphine exposure influences the ability of ibogaine to inhibit morphine-induced locomotor stimulation. Female Sprague-Dawley rats were pretreated once a day for 1–4 days with morphine (5, 10, 20 or 30 mg/kg, IP) or saline and then received ibogaine (40 mg/kg, IP) 5 h after the last morphine pretreatment dose. Compared to rats pretreated with saline, rats pretreated with morphine (10, 20 or 30 mg/kg, IP) before ibogaine (40 mg/kg, IP) showed a significant reduction in morphine-induced (5 mg/kg, IP) locomotor stimulation when tested 19 h after ibogaine administration. Furthermore, this effect was apparent over a range of ibogaine (5–60 mg/kg, IP) and morphine test (2.5–5 mg/kg, IP) dosages. Doses of ibogaine (5 and 10 mg/kg, IP) which alone were inactive inhibited morphine-induced locomotor activity when rats had been pretreated with morphine. These results, showing that morphine pre-exposure affects ibogaine activity, suggest that variable histories of opioid exposure might account for individual differences in the efficacy of ibogaine to inhibit opioid addiction.