An electrothermal atomic absorption method for aluminum analysis in plasma: identification of sources of contamination in blood sampling procedures.
An electrothermal atomic absorption method for aluminum analysis in plasma: identification of sources of contamination in blood sampling procedures.
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用于血浆中铝分析的电热原子吸收方法：血液采样过程中污染源的识别。
DOI：
10.1093/jat/7.1.20
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发表时间：
1983
影响因子：
2.5
通讯作者：
Kostyniak,PJ
中科院分区：
文献类型：
--
作者：
Kostyniak,PJ
报告的血清和血浆中铝浓度的“正常”值范围很广，这促使我们研究了通过原子吸收法测定铝的分析方法，并调查了可能的污染源，这可能导致文献中报告的结果差异很大。已经开发了一种方法，利用石墨炉，它给出了线性结果的铝浓度范围为2.5至100 ng Al/mL和0.6 ng/mL的检测限。在此浓度范围内，血浆中添加铝的回收率范围为89 - 100%。4名健康志愿者血浆中铝的平均浓度为2.7ng/mL。血液采样装置和肝素可能具有显著量的铝污染，这可以解释血浆和血清中引用的“正常”铝值的巨大差异。
A wide range of reported “normal” values for aluminum concentration in serum and plasma prompted the study of an analytical procedure for aluminum determination by atomic absorption and an investigation of possible sources of contamination, which may contribute to the wide variation in results reported in the literature. A method has been developed utilizing the graphite furnace, which gives linear results over an aluminum concentration range of 2.5 to 100 ng Al/mL and a limit of detection of 0.6 ng/mL. Recoveries of added aluminum from plasma ranged from 89 to 100% over this concentration range. The mean plasma concentration of aluminum found ln four healthy volunteers was 2.7 ng Al/mL. Blood sampling devices and heparin can have significant amounts of aluminum contamination, which may explain the large discrepancies ln quoted “normal” aluminum values in plasma and serum.