Effects of human hippocampal ablation.
Effects of human hippocampal ablation.
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DOI：
10.3171/jns.1967.26.4.0390
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发表时间：
1967-04
影响因子：
4.1
通讯作者：
A. Gol;G. Faibish
中科院分区：
文献类型：
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作者：
A. Gol;G. Faibish
Papez 5认为下丘脑、丘脑前核、扣带回、海马体及其连接构成了一个协调的机制，既可以发挥中枢情绪的功能，又可以参与情绪的表达。Herrick对边缘系统的功能提出了一个更广泛的概念，他认为边缘系统是所有新皮质功能的激活器，不仅促进或抑制情感行为，而且还促进记忆和学习。海马体本身被许多作者视为大脑边缘系统的“中枢”。Papez说，“皮层起源的中枢情绪过程”在海马形成中“建立”起来，然后再传递到乳头体和丘脑的前核。Grunthal 2表明，海马体作为“催化激活剂”，对中枢情感和新皮层活动至关重要。为了更深入地了解海马体的功能，在猫和猴子身上开发了一种海马体次全切除术技术。1,9海马切除术后，观察到明显的驯服效果，与kliliver和Bucy 4以及Sehreiner和KlingJ所描述的相似。在这些研究中，人们注意到海马切除术后动物对疼痛刺激的反应减弱。这是由于感知能力下降还是反应能力下降仍未确定。实验结果为进一步探讨海马切除术在临床水平上的作用提供了令人鼓舞的基础。这一过程似乎在精神外科和疼痛控制方面很有用。将实验室程序转移到临床水平充满了许多意想不到的陷阱，因此决定仅用于由广泛的癌性瘤病引起的顽固性疼痛
IlE hypothalamus, anterior thalamic nuclei, gyrus cinguli, hippoeampus, and their connections were believed by Papez 5 to constitute a harmonious mechanism which may elaborate the functions of central emotion as well as participate in emotional expression. A broader concept of the function of the limbic system was expressed by Herrick, 3 who considered the limbic system an activator of all neocortical functions facilitating or inhibiting not only affective behavior, but memory and learning as well. The hippocampus itself is regarded by many authors as the "hub" of the limbic system. Papez speaks of the "central emotive process of cortical origin" being "built up" in the hippocampal formation before being relayed to the mammillary bodies and the anterior nuclei of the thalamus. Grunthal 2 suggests that the hippocampus acts as a "catalytic activator" essential for the central affective and neocortical activity. To gain a greater insight into the function of the hippocampus, a technique for subtotal hippocampectomy was developed in the cat and monkey. 1,9 Following hippocampectomy, a marked taming effect was observed, similar to that described by Kliiver and Bucy 4 and Sehreiner and KlingJ During these studies it was noted that following hippocampectomy the animals showed less response to painful stimuli. Whether this was due to diminished perception or reactivity remained undetermined. The laboratory findings provided an encouraging basis for further exploration of the effects of hippocalnpectomy on a clinical level. It appeared that the procedure might prove useful in psychosurgery and pain control. The transfer of a laboratory procedure to the clinical level is fraught with many unexpected pitfalls, and it was decided, therefore, to use the procedure only for intractable pain due to widespread careinomatosis, or