Middle T antigen activation of signal transduction pathways does not overcome p53-mediated growth arrest.
Middle T antigen activation of signal transduction pathways does not overcome p53-mediated growth arrest.
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信号转导途径的中 T 抗原激活不能克服 p53 介导的生长停滞。
DOI：
10.1128/jvi.73.9.7882-7885.1999
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发表时间：
1999
影响因子：
5.4
通讯作者：
Freund,R
中科院分区：
文献类型：
--
作者：
Doherty,J;Freund,R
多瘤病毒中T抗原不能克服小鼠胚胎成纤维细胞中p53介导的G1期阻滞。中间T抗原仍然与信号分子磷脂酰肌醇3-激酶和SHC结合，并激活p53停滞细胞中c-Myc和AP 1的转录活性。细胞周期调节蛋白的检查表明，p53不干扰这些促有丝分裂信号，但在细胞周期的G1期后的行为。
Polyomavirus middle T antigen does not overcome p53-mediated G1arrest in mouse embryo fibroblasts. Middle T antigen still associates with the signaling molecules phosphatidylinositol 3-kinase and SHC and activates the transcriptional activity of c-Myc and AP1 in p53-arrested cells. Examination of cell cycle regulatory proteins indicated that p53 does not interfere with these mitogenic signals but acts later in the G1phase of the cell cycle.