Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster.
Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster.
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DOI：
10.1158/1055-9965.epi-10-0779
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发表时间：
2011-01
期刊：
影响因子：
--
通讯作者：
Madeleine MM
中科院分区：
文献类型：
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作者：
Johnson LG;Schwartz SM;Malkki M;Du Q;Petersdorf EW;Galloway DA;Madeleine MM
人乳头瘤病毒是宫颈癌的公认病因。我们假设，以对常见过敏原的超免疫反应为特征并与各种癌症相关的过敏可能与宫颈癌有关，并且与过敏相关的细胞因子基因的遗传变异可能影响宫颈癌的风险。我们调查了侵袭性鳞状细胞宫颈癌（SCC）的风险与自我报告的过敏和过敏相关细胞因子基因变异的关系，使用的数据来自华盛顿州进行的病例对照研究（561例，1258例对照）。Logistic回归模型得出优势比（OR）和95%置信区间（CI）。花粉过敏是最常见的过敏反应，与SCC风险降低相关（OR 0.6, 95% CI 0.5-0.8）。在覆盖8个基因（CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2）的60个标记单核苷酸多态性中，有几个与对照中的花粉过敏有关：IL4R rs3024647（显性OR 1.5 95% CI 1.0-2.3, p=0.04）， CSF2RB rs16997517（显性OR 2.2 95% CI 1.0-4.7, p=0.04）和IL13 rs1800925（每等位基因OR 1.7, 95% CI 1.3-2.4, p=0.0007）。两个变异与SCC风险呈负相关：IL4R rs3024656（每等位基因OR为0.8,95% CI 0.6-1.0, p=0.03）和CSF2RB rs16997517（显性OR为0.4,95% CI 0.2-0.9, p=0.04）。花粉过敏与SCC风险降低有关。CSF2RB rs16997517与对照组花粉过敏和降低SCC风险直接相关。如果其他研究证实了这些结果，那么在治疗性或预防性疫苗的背景下，与SCC风险相关的过敏相关免疫反应背后的机制可能值得探索。
Human papillomavirus is the acknowledged cause of cervical cancer. We hypothesized that allergies, characterized by hyperimmune reaction to common allergens andwhich have been associated with various cancers, may be related to cervical cancer, and that genetic variation in cytokine genes related to allergies might impact cervical cancer risk. We investigated the risk of invasive squamous cell cervical cancer (SCC) associated with self-reported allergies and with variation in allergy-related cytokine genes using data from a case-control study (561 cases, 1258 controls) conducted in Washington State. Logistic regression models yielded odds ratios (OR) and 95% confidence intervals (CI). Pollen allergy, the most commonly reported allergy, was associated with reduced SCC risk (OR 0.6, 95% CI 0.5–0.8). Of 60 tagging single nucleotide polymorphisms covering eight genes (CSF2, IL3, IL4, IL13, CSF2RB, IL4R, IL13RA1, IL13RA2), several were related to pollen allergies among controls: IL4R rs3024647 (dominant OR 1.5 95% CI 1.0–2.3, p=0.04), CSF2RB rs16997517 (dominant OR 2.2 95% CI 1.0–4.7, p=0.04), and IL13 rs1800925 (per-allele OR 1.7, 95% CI 1.3–2.4, p=0.0007). Two variants were inversely associated with SCC risk: IL4R rs3024656 (per-allele OR 0.8, 95% CI 0.6–1.0, p=0.03) and CSF2RB rs16997517 (dominant OR 0.4, 95% CI 0.2–0.9, p=0.04). Pollen allergies were related to reduced SCC risk. CSF2RB rs16997517 was directly related to pollen allergies in controls and to reduced SCC risk. If other studies confirm these results, the mechanism behind allergy-associated immune response associated with SCC risk may be worth exploring in the context of therapeutic or prophylactic vaccines.