Living-donor lobar lung transplantation experience: intermediate results.
Living-donor lobar lung transplantation experience: intermediate results.
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活体肺叶移植经验：中间结果。
DOI：
10.1016/s0022-5223(96)70142-3
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
F. A. Schenkel
中科院分区：
文献类型：
--
作者：
V. Starnes;M. Barr;R. Cohen;J. Hagen;W. Wells;M. Horn;F. A. Schenkel
目的活体肺叶移植为预期寿命不足几个月的患者提供了另一种选择。我们报告了有关受者生存、并发症、肺功能和血流动力学储备的中间结果。方法对 27 名成人和 10 名儿童患者进行了 38 例活体肺叶移植，治疗囊性纤维化 (32 例)、肺动脉高压 (2 例)、肺纤维化 (1 例)、病毒性细支气管炎 (1 例)、支气管肺发育不良 (1 例) 和移植后闭塞性细支气管炎（一）。 76名捐献者接受了供体肺叶切除术。结果37例患者中有14例死亡，平均随访14个月。主要原因是感染，这与我国人口中囊性纤维化患者比例较高的情况一致。排斥反应的总体发生率为 0.07 次/患者每月，即 0.8 次/患者。术后肺功能测试总体显示稳定改善，并在术后 9 至 12 个月达到稳定水平。随访至少 1 年的 14 名患者接受了右心导管检查；血压和肺血管阻力均在正常范围内。三名患者被明确诊断为闭塞性细支气管炎。在 76 名供者中，术后并发症包括心包切开术后综合征（3 例）、心房颤动（1 例）和手术再探查（3 例）。结论我们相信这些数据支持活体供体肺叶移植的作用扩大。我们的中间数据对于这些危重患者的功能结果和生存而言是令人鼓舞的，如果没有这种选择，他们就会死亡。 (胸心血管外科杂志 1996 年；112:1284-91)
ObjectiveLiving-donor lobar lung transplantation offers an alternative for patients with a life expectancy of less than a few months. We report on our intermediate results with respect to recipient survival, complications, pulmonary function, and hemodynamic reserve.MethodsThirty-eight living-donor lobar lung transplants were performed in 27 adult and 10 pediatric patients for cystic fibrosis (32), pulmonary hypertension (two), pulmonary fibrosis (one), viral bronchiolitis (one), bronchopulmonary dysplasia (one), and posttransplantation obliterative bronchiolitis (one). Seventy-six donors underwent donor lobectomies.ResultsThere were 14 deaths among the 37 patients, with an average follow-up of 14 months. Predominant cause of death was infection, consistent with the large percentage of patients with cystic fibrosis in our population. The overall incidence of rejection was 0.07 episodes/patient-month, representing 0.8 episodes/patient. Postoperative pulmonary function testing generally showed a steady improvement that plateaued by postoperative months 9 to 12. Fourteen patients who were followed up for at least 1 year underwent right heart catheterization; pressures and pulmonary vascular resistances were within normal ranges. Bronchiolitis obliterans was definitively diagnosed in three patients. Among the 76 donors, complications in the postoperative period included postpericardiotomy syndrome (three), atrial fibrillation (one), and surgical reexploration (three).ConclusionsWe believe that these data support an expanded role for living-donor lobar lung transplantation. Our intermediate data are encouraging with respect to the functional outcome and survival of these critically ill patients, who would have died without this option. (J Thorac Cardiovasc Surg 1996;112:1284-91)
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DOI：
--
发表时间：
1992
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Starnes,VA;Lewiston,N;Theodore,J;Stoehr,C;Stinson,E;Shumway,NE;Oyer,PE
通讯作者：
Oyer,PE
影响因子：
2.4
作者：
Starnes,VA;Marshall,SE;Lewiston,NJ;Theodore,J;Stinson,EB;Shumway,NE
通讯作者：
Shumway,NE
通过前瞻性、系列经支气管活检和肺功能研究对心肺移植受者进行评估。
DOI：
--
发表时间：
1989
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Starnes,VA;Theodore,J;Oyer,PE;Billingham,ME;Sibley,RK;Berry,G;Shumway,NE;Stinson,EB
通讯作者：
Stinson,EB
DOI：
10.1016/0003-4975(92)91338-a
发表时间：
1992
期刊：
The Annals of thoracic surgery
影响因子：
--
作者：
Starnes,VA;Oyer,PE;Bernstein,D;Baum,D;Gamberg,P;Miller,J;Shumway,NE
通讯作者：
Shumway,NE