Studies on Digitalis Glycosides. XXXII. Condensation of 17β-(3-Furyl)-5β, 14β-androstane-3β, 14, 16β-triol with Carbonyl Compounds
Studies on Digitalis Glycosides. XXXII. Condensation of 17β-(3-Furyl)-5β, 14β-androstane-3β, 14, 16β-triol with Carbonyl Compounds
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17β-(3-呋喃基)-5β, 14β-雄甾烷-3β, 14, 16β-三醇与羰基化合物的缩合研究。
DOI：
10.1248/cpb.18.1239
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
K. Aoyama
中科院分区：
文献类型：
--
作者：
D. Satoh;K. Aoyama
17β-（3-呋喃基）-5β，14β-雄甾烷-3 β，14，16β-三醇（Ⅲ）在无水硫酸铜或酸存在下与羰基化合物发生缩合反应，生成6 ′-取代-6 ′ H-5 β，14β-雄甾烷并[16，17- 2 ′，3 ′]呋喃并[3 ″，2 ″-4 ′，5 ′]吡喃-3 β，14-二醇（IV，IV'，IX，X）.通过光谱数据和化学转化确定了产物的结构。
A novel condensation reaction was found to take place between 17β-(3-furyl)-5β, 14β-androstane-3β, 14, 16β-triol (III) and carbonyl compounds in the presence of anhydrous cuppric sulfate or acid to afford 6'-substituted-6'H-5β, 14β-androstano [16, 17-2', 3'] furo [3'', 2''-4', 5'] pyran-3β, 14-diol (IV, IV', IX, X). The structures of these products were elucidated by their spectral data and chemical transformations.