Effects of prenatal morphine and cocaine exposure on spinal sexual reflexes in male and female rats.
Effects of prenatal morphine and cocaine exposure on spinal sexual reflexes in male and female rats.
复制标题
产前吗啡和可卡因暴露对雄性和雌性大鼠脊髓性反射的影响。
DOI：
10.1016/s0031-9384(97)00467-8
复制
发表时间：
1998
影响因子：
2.9
通讯作者：
Marson,L
中科院分区：
文献类型：
--
作者：
Vathy,I;Marson,L
Vathy，I.和L.Marson。孕期吗啡和可卡因暴露对雄性和雌性大鼠脊柱性反射的影响。PhysIOL Behaviv 63(3)445-450,1998.-先前的研究表明，在子宫内暴露于吗啡或可卡因会不同地改变成年的性行为，这依赖于雄性和雌性大鼠的循环性腺激素。在本研究中，研究了宫内吗啡和可卡因暴露对泌尿生殖系统反射的影响。在男性和女性中，泌尿生殖反射都被认为是一种不依赖激素的脊椎性反射。这种反射被脊髓上神经元强直抑制，但在脊髓横断动物中，刺激尿路可以持续地诱发这种反射。在脊椎完整的雄性或雌性大鼠中，出生前暴露于吗啡或可卡因并不能消除脊髓上对泌尿生殖反射的抑制。在脊柱横断的动物中，所有组的泌尿生殖反射在质量上都是相似的。然而，接触吗啡的男性需要更强的刺激才能引发泌尿生殖反射，但一旦激发，与对照组或接触可卡因的男性相比，泌尿生殖反射的频率明显更高。相比之下，在雌性大鼠中，出生前接触吗啡或可卡因对泌尿生殖系统反射没有任何影响。因此，男性和女性在产前接触吗啡似乎对泌尿生殖反射有不同的影响。
Vathy, I. and L. Marson. Effects of prenatal morphine and cocaine exposure on spinal sexual reflexes in male and female rats. PHYSIOL BEHAV 63(3) 445–450, 1998.—Previous studies demonstrated that in utero exposure to morphine or cocaine differentially alters adult sexual behaviors, which are dependent on circulating gonadal hormones in male and female rats. In the present study, the effects of in utero morphine and cocaine exposure on the urethrogenital reflex were examined. The urethrogenital reflex is thought to be a hormone-independent spinal sexual reflex in both males and females. This reflex is tonically inhibited by supraspinal neurons but can be consistently evoked by urethral stimulation in the spinally transected animals. Prenatal morphine or cocaine exposure did not remove the supraspinal inhibition of the urethrogenital reflex in spinally intact male or female rats. In spinally transected animals, the urethrogenital reflex was qualitatively similar in all groups. However, morphine-exposed males required a stronger stimulus to elicit the urethrogenital reflex but once elicited, the frequency of the urethrogenital reflex was significantly higher compared to either controls or cocaine-exposed males. In contrast, in female rats, neither prenatal morphine nor cocaine exposure had any effect on the urethrogenital reflex. Thus, the urethrogenital reflex appears to be differentially affected by prenatal exposure to morphine in males and females.