Secondary metabolite arsenal of an opportunistic pathogenic fungus
Secondary metabolite arsenal of an opportunistic pathogenic fungus
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DOI：
10.1098/rstb.2016.0023
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发表时间：
2016-12-05
影响因子：
6.3
通讯作者：
Keller, Nancy P.
中科院分区：
文献类型：
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作者：
Bignell, Elaine;Cairns, Timothy C.;Keller, Nancy P.
烟曲霉是一种多功能真菌，能够成功利用从哺乳动物肺部到农业废弃物的各种环境。在其众多适应度属性中，有数十个遗传位点含有生物合成基因簇（BGCs），这些基因簇产生生物活性小分子（通常称为次生代谢物或天然产物），为依赖环境的真菌提供生长优势。在这里，我们总结了目前对这些BGCs的了解-其中18可以命名为产物-它们在体内的表达谱，以及哪些BGCs可能增强这种机会性人类病原体的毒性。此外，我们发现了大量证据表明，在远亲属中存在许多此类BGCs或类似BGCs，包括新出现的病原体Pseudogymnoascus destructans（蝙蝠白鼻综合征的病原体），并表明此类BGCs可能预测其他真菌的致病潜力。这篇文章是主题“应对对动物健康、粮食安全和生态系统恢复力的新出现的真菌威胁”的一部分。
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments from mammalian lungs to agricultural waste products. Among its many fitness attributes are dozens of genetic loci containing biosynthetic gene clusters (BGCs) producing bioactive small molecules (often referred to as secondary metabolites or natural products) that provide growth advantages to the fungus dependent on environment. Here we summarize the current knowledge of these BGCs-18 of which can be named to product-their expression profiles in vivo, and which BGCs may enhance virulence of this opportunistic human pathogen. Furthermore, we find extensive evidence for the presence of many of these BGCs, or similar BGCs, in distantly related genera including the emerging pathogen Pseudogymnoascus destructans, the causative agent of white-nose syndrome in bats, and suggest such BGCs may be predictive of pathogenic potential in other fungi.This article is part of the themed issue 'Tackling emerging fungal threats to animal health, food security and ecosystem resilience'.