Spatial resolution of EEG cortical source imaging revealed by localization of retinotopic organization in human primary visual cortex
Spatial resolution of EEG cortical source imaging revealed by localization of retinotopic organization in human primary visual cortex
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DOI：
10.1016/j.jneumeth.2006.10.008
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发表时间：
2007-03-30
影响因子：
3
通讯作者：
He, Bin
中科院分区：
文献类型：
--
作者：
Im, Chang-Hwan;Gururajan, Arvind;He, Bin
本研究的目的是通过定位人类初级视觉皮层（VI）中的视网膜专题组织来研究脑电图（EEG）皮层源成像的空间分辨率。从功能磁共振成像（fMRI）研究中获得的 V I 视网膜主题特征被用作评估脑电图空间分辨率的参考，因为 fMRI 可以区分视野激活的微小变化。众所周知，由模式起始刺激引起的视觉诱发电位（VEP）中早期 Cl 成分的激活与 fMRI 定位的纹状皮层中的激活非常一致。在本实验中，我们沿着水平子午线移动小圆形棋盘刺激，并将脑电图皮层源成像与 tMRI 的局部激活进行比较。 fMRI 和 EEG 皮层源成像都识别出每个研究对象的 V I 内的空间相关活动。 VI 中 fMRI 确定的激活中心与等效 CI 分量（峰值潜伏期：74.8 +/- 10.6 ms）估计的 EEG 源成像激活峰值之间的平均位置误差为 7 毫米（25% 和 75% 百分位数分别为 6.45 毫米和 8.4 毫米），小于 fMRI 激活图 3 度视野变化（7.8 毫米）的变化。此外，最早主要 VEP 成分的源估计在统计上与 fMRI 获得的估计显示出良好的相关性。目前的结果表明，EEG 皮质源成像的空间分辨率可以正确区分 V I 中与小于 3 度视野变化相对应的皮质激活变化。 (c) 2006 Elsevier B.V. 保留所有权利。
The aim of the present study is to investigate the spatial resolution of electroencephalography (EEG) cortical source imaging by localizing the retinotopic organization in the human primary visual cortex (VI). Retinotopic characteristics in V I obtained from functional magnetic resonance imaging (fMRI) study were used as reference to assess the spatial resolution of EEG since fMRI can discriminate small changes in activation in visual field. It is well known that the activation of the early Cl component in the visual evoked potential (VEP) elicited by pattern onset stimuli coincides well with the activation in the striate cortex localized by fMRI. In the present experiments, we moved small circular checkerboard stimuli along horizontal meridian and compared the activations localized by EEG cortical source imaging with those from tMRI. Both fMRI and EEG cortical source imaging identified spatially correlated activity within V I in each subject studied. The mean location error, between the fMRI-determined activation centers in VI and the EEG source imaging activation peak estimated at equivalent CI components (peak latency: 74.8 +/- 10.6 ms), was 7 mm (25% and 75% percentiles are 6.45 mm and 8.4 mm, respectively), which is less than the change in fMRI activation map by a 3 degrees visual field change (7.8 mm). Moreover, the source estimates at the earliest major VEP component showed statistically good correlation with those obtained by fMRI. The present results suggest that the spatial resolution of the EEG cortical source imaging can correctly discriminate cortical activation changes in V I corresponding to less than 3 degrees visual field changes. (c) 2006 Elsevier B.V. All rights reserved.