N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS DISRUPT THE FORMATION OF A MAMMALIAN NEURAL MAP
N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS DISRUPT THE FORMATION OF A MAMMALIAN NEURAL MAP
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DOI：
10.1073/pnas.89.22.10593
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发表时间：
1992-11-15
影响因子：
11.1
通讯作者：
CONSTANTINEPATON, M
中科院分区：
文献类型：
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作者：
SIMON, DK;PRUSKY, GT;CONSTANTINEPATON, M
大鼠上丘视网膜连接的地形图排列是在出生后早期从最初的弥漫投射中出现的。在此期间，上丘N-甲基-D-天冬氨酸(NMDA)受体活性的破坏干扰了MAP的重塑。在出生后头两周长期接受NMDA受体拮抗剂治疗的大鼠，异常轴突仍然存在，并在地形错误的位置树枝状分布。这些结果表明，在视觉诱发活动之前的一个阶段，正常的NMDA受体功能对于哺乳动物大脑中有序的神经图谱的发展是重要的。
The topographic ordering of retinal connections in the rat superior colliculus emerges during early postnatal life from an initially diffuse projection. Disruption of N-methyl-D-aspartate (NMDA) receptor activity in the superior colliculus during this period interferes with map remodeling. In rats chronically treated with NMDA receptor antagonists during the first two postnatal weeks, aberrant axons remain and arborize at topographically incorrect sites. These results indicate that, at a stage preceding visually evoked activity, normal NMDA receptor function is important for the development of an ordered neural map in the mammalian brain.