Study of the Relationship Between Ultrasound Strain Indices and Cognitive Decline for Vulnerable Carotid Plaque.
Study of the Relationship Between Ultrasound Strain Indices and Cognitive Decline for Vulnerable Carotid Plaque.
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DOI：
10.1109/embc44109.2020.9175911
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发表时间：
2020-07
期刊：
影响因子：
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通讯作者：
Varghese T
中科院分区：
文献类型：
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作者：
Meshram NH;Jackson D;Mitchell CC;Wilbrand SM;Dempsey RJ;Hermann BP;Varghese T
在 42 名有症状患者和 34 名无症状患者中研究了颈动脉斑块超声应变指数与执行和语言功能认知领域之间的关系。有症状和无症状患者的狭窄百分比平均值和标准差分别为 72.10 ± 15.19 和 77.41 ± 11.20。进行了轴向、横向和剪切应变指数与执行和语言综合评分之间的 Pearson 相关性。发现有症状患者的执行和语言功能与应变指数存在显着的负相关。另一方面，对于无症状患者，只有执行功能与相应的应变指数呈负相关。我们的假设是，易损斑块产生的微栓子和可能的“无症状中风”可能是有症状和无症状患者执行功能下降的原因”。中风和短暂性脑缺血发作可能是有症状患者语言功能认知进一步下降的原因。
A relationship between ultrasound strain indices in carotid plaque to cognitive domains of executive and language function are studied in 42 symptomatic and 34 asymptomatic patients. The mean and standard deviation of the percentage stenosis were 72.10 ± 15.19 and 77.41 ± 11.20 for symptomatic and asymptomatic patients respectively. Pearson’s correlation between axial, lateral and shear strain indices versus executive and language composite scores was performed.. A significant inverse correlation for both executive and language function for symptomatic patients to strain indices was found. On the other hand, for asymptomatic patients only executive function was inversely correlated with the corresponding strain indices. Our hypothesis that micro-emboli from vulnerable plaque and possible ‘silent strokes’ may be responsible for decline in executive function for both symptomatic and asymptomatic patients’. Strokes and transient ischemic attacks may be responsible for further cognitive decline in language function for symptomatic patients.