Interleukin-6 as a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery.
Interleukin-6 as a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery.
复制标题
白细胞介素6作为炎症状态新指标：手术后血清白细胞介素6和C反应蛋白水平的检测
作者：
Hiroki Ohzato;K. Yoshizaki;N. Nishimoto;Atsushi Ogata;Hiromi Tagoh;Morito Monden;Mitsukazu Gotoh;Tadamitsu Kishimoto;Takesada Mori
对71例腹部手术患者术后血清白介素6(sIL-6)和C反应蛋白(SCRP)水平进行了检测。尽管不同的手术方法和肝功能不同，但12名患者的sIL-6和SCRP水平也有类似的时间依赖性变化。SIL-6在手术开始后3小时内开始升高，24小时后达到高峰。SCRP在12小时后开始升高，48~72小时达到最大值。53例非肝硬化组患者24小时血清sIL-6水平(βIL-6)与48小时血清C反应蛋白(C反应蛋白)水平呈正相关。在18例肝硬化组中，β-CRP与β-IL-6的比值低于非肝硬化组，且与非肝硬化组相关性差。两组中Delta IL-6与手术时间和出血量相关，但Delta CRP与这些因素均无显著相关性。这些结果表明，外科手术引起的IL-6升高可能是一种肝细胞刺激因子，监测sIL-6可能比监测SCRP更有助于评估炎症状态和早期发现急性期反应。
Postoperative serum interleukin-6 (SIL-6) and C-reactive protein (SCRP) levels were examined in 71 patients who underwent various types of abdominal surgery. Similar time-dependent changes in SIL-6 and SCRP levels were observed in 12 patients despite differences in surgical procedures and liver function among the patients. SIL-6 started to increase within 3 hours after the beginning of the operation and reached a peak after 24 hours. SCRP started to increase after 12 hours and was maximum at 48 to 72 hours. The increase in SIL-6 at 24 hours (delta IL-6) showed a close correlation with that of SCRP at 48 hours (delta CRP) in 53 patients without liver cirrhosis. In 18 patients with liver cirrhosis, delta CRP relative to delta IL-6 was less than that in patients without cirrhosis and was poorly correlated with the latter. delta IL-6 was correlated with the length of time of the operation and blood loss in both groups, but delta CRP showed no significant correlation with these factors in either group. These findings indicate that the increase in IL-6 triggered by a surgical procedure may function as a hepatocyte-stimulating factor and that monitoring of SIL-6 may be more helpful than monitoring of SCRP for estimation of inflammatory status and early detection of an acute-phase response.