Changes in the Distribution of HIV Type 1 Subtypes D and A in Rakai District, Uganda Between 1994 and 2002
Changes in the Distribution of HIV Type 1 Subtypes D and A in Rakai District, Uganda Between 1994 and 2002
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DOI：
10.1089/aid.2010.0054
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发表时间：
2010-10-01
影响因子：
1.5
通讯作者：
Quinn, Thomas C.
中科院分区：
文献类型：
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作者：
Conroy, Samantha A.;Laeyendecker, Oliver;Quinn, Thomas C.
HIV-1亚型D（HIV-1D）比亚型A（HIV-1A）发展为疾病更快，传播性更低。我们研究了这些差异是否会导致这些亚型的分布随时间发生群体水平的变化。从1994年和2002年在乌干达Rakai进行的一项基于人群的队列研究中HIV阳性受试者的储存血清样本中提取HIV-1病毒RNA。对病毒蛋白gag和gp 41的部分进行测序和分型。1994年为773名受试者分配了HIV-1亚型，2002年为812名受试者。使用线性模型检查整个人群以及四分位数年龄组的亚型分布变化是否存在显著变化。在8年期间，感染HIV-1D的受试者比例从70.2%显著下降至62.4%，感染HIV-1A的受试者比例从16.7%显著增加至23.3%（p = 0.005）。HIV-1D和A的比例变化最明显的是年轻人（
HIV-1 subtype D (HIV-1D) progresses to disease faster and has lower transmissibility than subtype A (HIV-1A). We examined whether these differences could lead to a population level change in the distribution of these subtypes over time. HIV-1 viral RNA was extracted from stored serum samples from HIV-positive subjects participating in a population-based cohort study in Rakai, Uganda in 1994 and 2002. Portions of the viral proteins gag and gp41 were sequenced and subtyped. HIV-1 subtype assignments were generated for 773 subjects in 1994 and 812 subjects in 2002. The change in subtype distribution of the population as a whole as well as quartile age groups were examined for significant changes using a linear model. There was a significant decrease in the proportion of subjects infected with HIV-1D from 70.2% to 62.4% and a significant increase in subjects infected with HIV-1A from 16.7% to 23.3% over the 8-year period (p = 0.005). The most marked changes in proportion of HIV-1D and A were seen in the younger individuals (