Association of dietary zinc intake with coronary artery calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA)
Association of dietary zinc intake with coronary artery calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA)
复制标题
膳食锌摄入量与冠状动脉钙进展的关系：动脉粥样硬化多种族研究 (MESA)
DOI：
10.1007/s00394-020-02452-5
复制
发表时间：
2021-01-04
影响因子：
5
通讯作者：
Liu, Pin-Ming
中科院分区：
文献类型：
--
作者：
Gao, Jing-Wei;Zhang, Shao-Ling;Liu, Pin-Ming
锌被认为对动脉粥样硬化有保护作用;然而，膳食锌摄入量与心血管疾病之间的关系仍存在争议。我们调查了饮食中锌的摄入量是否与冠状动脉钙（CAC）进展的多种族研究动脉粥样硬化（梅萨）methodsThis分析包括5186名参与者，年龄61.9 ± 10.2岁（48.8%的男性，41.3%白色，25.0%黑色，21.6%西班牙裔，12.1%中国美国人）从梅萨。在基线（2000-2002年）通过自我管理的120项食物频率问卷评估饮食锌摄入量。通过计算机断层扫描测量基线和随访CAC。CAC进展被定义为CAC > 0在后续的参与者与CAC = 0在baseline;和一个10或百分比变化≥ 10%的那些0 < CAC < 100或CAC ≥ 100在baseline，respectively.ResultsDietary Zn intake was 8.4 ± 4.5 mg/day and 2537（48.9%）的参与者有CAC在baseline。中位随访时间为3.4年（第25 - 75个月= 2.0-9.1年），2704（52.1%）例参与者发生CAC进展。在完全校正的模型中，较高的饮食锌与男性（风险比[HR] 0.697，95%置信区间[CI] 0.553-0.878;p= 0.002）和女性（HR 0.675; 95% CI 0.496-0.919;p= 0.012，均比较极端组）的CAC进展风险较低相关。此外，这种负相关可归因于非红肉的膳食锌摄入量（p< 0.05），而不是红肉来源（p> 0.05）.ConclusionsIn this multiethnic population free of clinical apparent cardiovascular diseases，higher dietary zinc intake from non-red meat sources is independently associated with a lower risk of CAC progression.Clinical trial registration number梅萨trial was registered at clinicaltrials.gov as NCT 00005487.
PurposeZinc is considered protective against atherosclerosis; however, the association between dietary zinc intake and cardiovascular disease remains debated. We investigated whether dietary zinc intake was associated with coronary artery calcium (CAC) progression in the Multi-Ethnic Study of Atherosclerosis (MESA).MethodsThis analysis included 5186 participants aged 61.9 ± 10.2 years (48.8% men; 41.3% white, 25.0% black, 21.6% Hispanic, and 12.1% Chinese American) from the MESA. Dietary zinc intake was assessed by a self-administered, 120-item food frequency questionnaire at baseline (2000–2002). Baseline and follow-up CAC were measured by computed tomography. CAC progression was defined as CAC > 0 at follow-up for participants with CAC = 0 at baseline; and an annualized change of 10 or percent change of ≥ 10% for those with 0 < CAC < 100 or CAC ≥ 100 at baseline, respectively.ResultsDietary zinc intake was 8.4 ± 4.5 mg/day and 2537 (48.9%) of the included participants had CAC at baseline. Over a median follow-up of 3.4 years (25th–75th percentiles = 2.0–9.1 years), 2704 (52.1%) participants had CAC progression. In the fully adjusted model, higher dietary zinc was associated with a lower risk of CAC progression in both men (hazard ratio [HR] 0.697, 95% confidence interval [CI] 0.553–0.878;p= 0.002) and women (HR 0.675; 95% CI 0.496–0.919;p= 0.012, both comparing extreme groups). Furthermore, such an inverse association was attributable to dietary zinc intake from non-red meat (p< 0.05), rather than red meat sources (p> 0.05).ConclusionsIn this multiethnic population free of clinically apparent cardiovascular disease, higher dietary zinc intake from non-red meat sources was independently associated with a lower risk of CAC progression.Clinical trial registration numberThe MESA trial was registered at clinicaltrials.gov as NCT00005487.