PRESENCE OF ERGOTHIONEINE IN CENTRAL NERVOUS SYSTEM AND ITS PROBABLE IDENTITY WITH CEREBELLAR FACTOR
PRESENCE OF ERGOTHIONEINE IN CENTRAL NERVOUS SYSTEM AND ITS PROBABLE IDENTITY WITH CEREBELLAR FACTOR
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DOI：
10.1113/jphysiol.1966.sp007830
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发表时间：
1966-01-01
影响因子：
5.5
通讯作者：
WOODRUFF, GN
中科院分区：
文献类型：
--
作者：
CROSSLAND, J;MITCHELL, JF;WOODRUFF, GN
已在小鼠、大鼠、豚鼠、兔、猫和绵羊的脑中检测到麦角硫因并进行了定量估计。它存在于小脑中，含量范围为猫的约3.0 [mu]g/g至豚鼠的10 [mu]g/g。大脑半球中的含量要小得多，从猫的< 0.1 [mu]g/g到豚鼠的1.6 [mu]g/g不等。在家兔的视神经中发现大量麦角硫因（约30 [mu]g/g）。在同种动物的脊髓背柱中均未检测到。麦角硫因对去大脑家兔小脑的电活动具有兴奋作用，小脑提取物对该制剂的兴奋作用完全由其所含的麦角硫因来解释。Crossland和Mitchell（1956）的小脑因子与麦角硫因相同。
Ergothioneine has been detected and quantitatively estimated in the brains of mice, rats, guinea-pigs, rabbits, cats and sheep. It is present in the cerebellum in amounts ranging from about 3.0 [mu]g/g in the cat to 10 [mu]g/g in the guinea-pig. Amounts in the cerebral hemispheres are much smaller, ranging from < 0.1 [mu]g/g in the cat to 1,6 [mu]g/g in the guinea-pig. Large amounts of ergothioneine (about 30 [mu]g/g) were found in the optic nerves of the rabbit. None was detected in the dorsal columns of the spinal cord of the same species. Ergothioneine has an excitatory action on the electrical activity of the cerebellum of the decerebrate rabbit and the excitatory actions of cerebellar extracts on this preparation are completely accounted for by their contained ergothioneine. The cerebellar factor of Crossland and Mitchell (1956) is identical with ergothioneine.