Human Population Differentiation Is Strongly Correlated with Local Recombination Rate
Human Population Differentiation Is Strongly Correlated with Local Recombination Rate
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DOI：
10.1371/journal.pgen.1000886
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发表时间：
2010-03-01
期刊：
影响因子：
4.5
通讯作者：
Reich, David
中科院分区：
文献类型：
--
作者：
Keinan, Alon;Reich, David
群体间等位基因频率的差异可以为研究群体结构和识别自然选择的目标基因座提供有价值的信息。在这里，我们通过分析两个统一确定的全基因组数据集来研究人类重组率和群体分化之间的关系。结果表明，用洲际F-ST评价的群体分化与重组率呈负相关，重组率最高的10个基因组的F-ST比重组率最低的10个基因组的F-ST降低了10%（P
Allele frequency differences across populations can provide valuable information both for studying population structure and for identifying loci that have been targets of natural selection. Here, we examine the relationship between recombination rate and population differentiation in humans by analyzing two uniformly-ascertained, whole-genome data sets. We find that population differentiation as assessed by inter-continental F-ST shows negative correlation with recombination rate, with F-ST reduced by 10% in the tenth of the genome with the highest recombination rate compared with the tenth of the genome with the lowest recombination rate (P