Novel integrative genomics strategies to identify genes for complex traits.
Novel integrative genomics strategies to identify genes for complex traits.
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DOI：
10.1111/j.1365-2052.2006.01473.x
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发表时间：
2006-08
期刊：
影响因子：
2.4
通讯作者：
Schadt, E E
中科院分区：
文献类型：
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作者：
Schadt, E E
正向遗传学是一种剖析常见人类疾病的复杂特征的常见方法。在进化过程中产生突变的基因或由于化学诱变而产生的突变，因此导致疾病或其他感兴趣的表型的变化。最近，这种方法在生物网络的一部分中的作用是系统地错过的，已经设计出一种新型的综合基因组方法，以阐明通过基因型，分子分析和临床分子和临床的共同人类疾病的复杂性这些新颖的方法中的数据对生物系统具有更全面的看法，并利用了庞大的基因 - 基因相互作用网络，并结合DNA变异数据，以建立分子特征性状和fbet的因果关系其他经典表型）是由于这些方法的结果确定了许多新型疾病表型的基因，这突出了整合正交数据来源以使疾病基本原因的实用性。
Forward genetics is a common approach to dissecting complex traits like common human diseases. The ultimate aim of this approach was the identification of genes that are causal for disease or other phenotypes of interest. However, the forward genetics approach is by definition restricted to the identification of genes that have incurred mutations over the course of evolution or that incurred mutations as a result of chemical mutagenesis, and that as a result lead to disease or to variations in other phenotypes of interest. Genes that harbour no such mutations, but that play key roles in parts of the biological network that lead to disease, are systematically missed by this class of approaches. Recently, a class of novel integrative genomics approaches has been devised to elucidate the complexity of common human diseases by intersecting genotypic, molecular profiling, and clinical data in segregating populations. These novel approaches take a more holistic view of biological systems and leverage the vast network of gene–gene interactions, in combination with DNA variation data, to establish causal relationships among molecular profiling traits and Fbetween molecular profiling and disease (or other classic phenotypes). A number of novel genes for disease phenotypes have been identified as a result of these approaches, highlighting the utility of integrating orthogonal sources of data to get at the underlying causes of disease.