Schizophrenia and risk of dementia: a meta-analysis study.
Schizophrenia and risk of dementia: a meta-analysis study.
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DOI：
10.2147/ndt.s172933
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发表时间：
2018
影响因子：
3.2
通讯作者：
Huang J
中科院分区：
文献类型：
--
作者：
Cai L;Huang J
有证据表明，精神分裂症可能与痴呆症的风险增加有关，但以前的研究结果并不一致。本研究旨在使用定量荟萃分析评估精神分裂症与痴呆事件之间的关系。使用多个数据库收集相关信息，包括PubMed、Embase和Web of Science，文章的发表日期限制为2017年12月23日。所有研究报告了精神分裂症与痴呆发病率风险之间关系的多变量校正估计值，表示为相对风险（RR）和95%置信区间（CI）。使用随机效应模型计算汇总RR。六项研究符合我们的荟萃分析纳入标准，其中包括206，694例痴呆病例和5，063，316名参与者。所有人在基线时都没有痴呆症。总体而言，定量荟萃分析表明，精神分裂症受试者与痴呆发病率的风险显著高于非精神分裂症受试者（RR 2.29; 95%CI 1.35-3.88）。这项荟萃分析的结果表明，精神分裂症患者患痴呆症的风险可能会增加。未来的研究应该探讨精神分裂症是否是痴呆症的一个可改变的危险因素。
Evidence suggests that schizophrenia may be associated with an increased risk of dementia, but results from prior studies have been inconsistent. This study aimed to estimate the relationship between schizophrenia and incident dementia using a quantitative meta-analysis. Several databases were used to gather relevant information, including PubMed, Embase, and Web of Science, with the publication date of articles limited up to December 23, 2017. All studies reported a multivariate-adjusted estimate, represented as relative risk (RR) with 95% confidence intervals (CIs), for the association between schizophrenia and risk of dementia incidence. Pooled RRs were calculated using a random-effects model. Six studies met our inclusion criteria for this meta-analysis, which included 206,694 cases of dementia and 5,063,316 participants. All individuals were without dementia at baseline. Overall, the quantitative meta-analysis suggested that subjects with schizophrenia were associated with a significantly greater risk of dementia incidence (RR 2.29; 95% CI 1.35–3.88) than those without. The results of this meta-analysis indicate that individuals with schizophrenia may have an increased risk for the development of dementia. Future studies should explore whether schizophrenia is a modifiable risk factor for dementia.